胃癌中糖基化研究进展与临床应用
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i6.17050
Abstract
胃癌的高死亡率亟待在其分子机制与临床诊疗策略上取得突破。糖基化失调是胃癌的关键分子特征。本综述系统阐释了胃癌中复杂的糖基化调控网络，包括异常的N-聚糖分支与唾液酸化、截短O-聚糖（如STn）的积聚，以及关键酶失衡驱动的O-GlcNAc修饰。这些变化调控了细胞粘附与信号传导等恶性表型，是驱动胃癌进展的关键环节。尤为重要的是，这些异常的糖基化模式展现出显著的转化医学前景：特定的糖基化特征（如血清聚糖图谱）在诊断与预后判断上优于传统标志物。本文旨在系统梳理该领域进展，为胃癌的精准诊断与预后评估提供新的思路。
Keywords
胃癌；N-糖基化；O-糖基化；血清生物标志物
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[4] Parreira P, Magalhães A, Reis C A, et al. Bioengineered surfaces promote specific protein-glycan mediated binding of the gastric pathogen Helicobacter pylori[J]. Acta Biomater, 2013, 9(11): 8885-8893.
[5] 李兆申.慢性萎缩性胃炎的早筛、早诊、早治与胃癌的预防[J].中华消化杂志,2021,41(Z1):5-8.
[6] Fuster M M, Esko J D. The sweet and sour of cancer: glycans as novel therapeutic targets[J]. Nat Rev Cancer, 2005, 5(7): 526-542.
[7] Pinho S S, Alves I, Gaifem J, et al. Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection[J]. Cell Mol Immunol, 2023, 20(10): 1101-1113.
[8] Fernandes E, Sores J, Cotton S, et al. Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology[J]. Theranostics, 2020, 10(11): 4903-4928.
[9] Häuselmann I, Borsig L. Altered tumor-cell glycosylation promotes metastasis[J]. Front Oncol, 2014,4(28).
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