参附注射液对心脏骤停后脑缺血再灌注损伤保护作用机制的研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i6.17016
Abstract
脑缺血再灌注损伤是心脏骤停（CA）后患者不可避免的关键病理生理过程，严重影响患者的存活率和远期神经功能预后。脑缺血再灌注损伤的主要机制包括炎症级联反应、氧化应激、钙超载、血脑屏障破坏、能量代谢障碍、诱导神经细胞凋亡等。参附注射液（SFI）作为传统中药复方制剂，具有益气回阳、扶正固脱的功效，近年研究表明其对 CA 后脑缺血再灌注损伤（CIRI）具有潜在保护作用。本文主要对参附注射液在 CA 后缺血再灌注脑损伤保护作用的研究进展及其未来前景展开综述，为优化复苏后脑损伤治疗策略提供理论依据。
Keywords
参附注射液；心脏骤停；脑缺血再灌注；心肺复苏；脑保护
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[3] 中华医学会急诊医学分会复苏学组,中国医药教育协会急诊专业委员会,成人心脏骤停后综合征诊断和治疗中国急诊专家共识组.成人心脏骤停后综合征诊断和治疗中国急诊专家共识[J].中华急诊医学杂志,2021,30(07):799-808.
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[5] DENG H, TANG Z, TUO P, et al. Shenfu Injection Protects Brain Injury in Rats with Cardiac Arrest through Nogo/NgR Pathway [J]. Anal Cell Pathol (Amst), 2022, 2022: 4588999.
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[9] 胡海霞.舒芬太尼对大鼠心肺复苏后脑保护作用及其机制探讨[D];吉林大学,2022.
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