蛋白质稳态失衡在衰老相关认知衰退中的作用机制研究
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i3.14436
Abstract
随着年龄的增长,人体内的蛋白质稳态逐渐受到挑战,进而影响细胞功能和组织健康。蛋白质稳态的失衡被认为是衰老相关认知衰退的重要机制之一。本研究旨在探讨蛋白质稳态失衡在衰老过程中的作用,尤其是其在认知功能衰退中的潜在影响。通过分析蛋白质合成、折叠、降解及其在衰老过程中的变化,本文阐述了蛋白质稳态失衡如何通过引发蛋白质聚集、神经元损伤以及细胞老化,进而导致认知功能的衰退。此外,本文还探讨了通过基因编辑、激活自噬等方法恢复蛋白质稳态的可能性,提出了多种潜在的干预策略。
Keywords
蛋白质稳态；认知衰退；蛋白质聚集；基因编辑；干预策略
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