耐碳青霉烯类肺炎克雷伯杆菌的耐药机制研究
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i1.11853
Abstract
肺炎克雷伯杆菌(Klebsiella pneumoniae)作为重要的致病菌之一,其耐碳青霉烯类抗生素的显著增加,已成为全球公共卫生的重大挑战。近年来,关于肺炎克雷伯杆菌耐药机制的研究逐渐深入,涉及多种生物学机制和基因突变。当前的研究显示,耐药机制主要包括β-内酰胺酶的产生、细胞膜通透性改变以及抗性基因的传播等。这些机制的复杂性以及其在不同菌株中的变异性,使得对抗耐药肺炎克雷伯杆菌的治疗变得愈加困难。因此,深入理解其耐药机制,不仅对临床治疗策略的制定至关重要,也为未来新型抗生素的研发提供了重要的基础。本综述旨在系统探讨耐碳青霉烯类肺炎克雷伯杆菌的主要耐药机制,以期为相关研究和临床实践提供参考。
Keywords
肺炎克雷伯杆菌；碳青霉烯类抗生素；耐药机制；β-内酰胺酶
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