虚弱和非酒精性脂肪肝病的孟德尔随机化研究
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i1.11845
Abstract
目的：许多临床和基础研究表明虚弱和非酒精性脂肪肝病之间存在关联,然而,它们的因果关系目前尚不清楚。本研究旨在利用大规模人群全基因组关联研究(GWAS)汇总数据研究虚弱和非酒精性脂肪肝病之间的遗传因果关系。方法：使用双样本孟德尔随机化(MR)研究探讨虚弱和非酒精性脂肪肝病之间是否存在因果关系。随机效应逆方差加权(IVW)荟萃分析是主要的分析方法,MR Egger、加权中位数、简单模态和加权模态作为辅助方法。随后,我们使用了IVW、MR-Egger、MR-PRESSO和留一法分析进行异质性和水平多效性测试。结果：随机效应IVW结果显示,虚弱[p<0.00001,OR95%CI =3.149(1.894-5.236)]与非酒精性脂肪肝病有遗传因果关系,且敏感性分析并未发现异质性和水平多效性。结论：我们的研究发现虚弱和非酒精性脂肪肝病存在遗传因果关系,这可能为理解虚弱的生物学机制及其与NAFLD等代谢相关肝病的病因学联系提供新的证据和研究思路。
Keywords
虚弱；非酒精性脂肪肝病；孟德尔随机化；遗传分析
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