ID及IDA对儿童大脑发育影响的研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i1.11816
Abstract
铁缺乏(iron deficiency anemia,ID)和缺铁性贫血(iron deficiency anemia,IDA)是全球范围内最常见的单一营养缺乏性疾病,在孕妇及儿童群体中高发。因该病症具有隐匿性,往往易被忽视,然而一旦发生,将会给儿童的健康以及正常生长发育带来极为严重的影响,尤其是对脑发育有着长期且不可逆的损害,从而出现智能发育落后、倒退甚至行为异常。动物研究和人类研究均发现,经过铁剂补充纠正受损的功能仍然不能完全恢复。因此,本文综述了ID和IDA对儿童大脑发育的影响,从而树立预防大于治疗的观念,积极开展铁缺乏相关疾病的预防和干预、神经发育障碍性疾病的防控,为促进儿童发展提供了全新的思路。
Keywords
铁缺乏；缺铁性贫血；脑发育
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[4] 邵洁,高嘉滢.营养与生命早期脑发育[J].中国儿童保健杂志,2024,32(04):368-371.
[5] 章逸莉,郑双双,朱柳燕,等.生命早期不同时期铁缺乏对儿童运动发育影响的纵向研究[J].中华儿科杂志,2019,57(3):194-199.
[6] Hua M,Shi D,Xu W,et al.Differentiation between fetal and postnatal iron deficiency in altering brain substrates of cognitive control in pre-adolescence[J].BMC Medicine,2023, 21(1).https://doi.org/10.1186/s12916-023-02850-6.
[7] Geng F,Mai X,ZhanJ,et al.Timing of iron deficiency and recognition memory in infancy[J].Nutr Neurosci,2020,25(1):1-10.
[8] Lou J,Mai X,Lozoff B,et al.Prenataliron deficiency and auditory brainstem responses at 3 and 10 months:A pilot study[J].Hong Kong J Paediatr,2016,20(2):71-79.
[9] 吴丹青,程锐.早产儿贫血及其防治的研究进展[J].现代医学,2022,50(7):924-927.
[10] Bastian TW, Von Hohenberg WC, Mickelson DJ, Lanier LM, Georgieff MK. Iron deficiency impairs developing hippocampal neuron gene expression, energy metabolism, and dendrite complexity.Dev Neurosci.2016;38(4):264-76.
[11] Ward KL, Tkac I, Jing Y, Felt B, Beard J, Connor J, et al. Gestational and lactational iron deficiency alters the developing striatal metabolome and associated behaviors in young rats.J Nutr.2007;137(4):1043-9.
[12] Unger EL, Paul T, Murray-Kolb LE, Felt B, Jones BC, Beard JL. Early iron deficiency alters sensorimotor developme nt and brain monoamines in rats.J Nutr.2007;137(1):118-24.
[13] Hua,M.,Shi,D., Xu, W.et al.Differentiation between fetal and postnatal iron deficiency in altering brain substra tes of cognitive control in pre-adolescence.BMC Med21,167(2023).
[14] Kordas K, Tondeur MC, Spieldenner K. Iron deficiency in infancy and neurocognitive development.Clin Nutr. 2019;38 (4):1520-1530.
[15] Algarín C, Peirano P, Garrido M, et al.Iron Deficiency Anemia in Infancy: Long-Lasting Effects on Auditory and Visual System Functioning[J].Pediatric Research.2003, 53 (2):217-223.
[16] 毛莉.不同严重程度缺铁性贫血对婴幼儿神经行为发育的影响[J].中国妇幼保健,2022,37(12):2196-2199.
[17] Mirzaei A, Sadeghi M, Moghaddam SS, et al. Prevalence of iron deficiency anemia in Iranian children under 6 years of age: a systematic review and meta-analysis.[J]. J Blood Med.2021;12:391-403.
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