自噬在衰老相关肌少症的研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i1.11814
Abstract
随着全球人口老龄化加剧,与年龄相关的肌肉减少症发病率越来越高。肌肉减少症表现肌肉力量质量降低以及身体机能降低,与跌倒和残疾风险增加密切相关,给个人、社会和经济带来沉重负担。在众多肌少症病理生理机制中,自噬占有一席之地。自噬是一种重要的细胞自我保护机制,通过溶酶体降解错误折叠的蛋白质和受损的细胞器,维持细胞稳定。自噬可以通过调节卫星细胞的再生能力、缓解氧化应激、抑制炎症反应和抗凋亡来缓解肌少症。本文综述了肌肉减少症与自噬之间的特定相互作用,并探索其可能的治疗方法,希望能寻找到更多有用的具体研究,为改善肌少症带来更多有前途的治疗方法。
Keywords
骨骼肌;衰老;肌少症;自噬;治疗
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[1] ROSENBERG I H.Sarcopenia:origins and clinical relevan ce[J/OL].Clinics in Geriatric Medicine,2011,27(3):337-339.
[2] CRUZ-JENTOFT A J,BAHAT G, BAUER J, et al. Sarcopenia: revised European consensus on definition and diagnosis[J/OL]. Age and Ageing,2019,48(4):601.
[3] DENNISON E M, SAYER A A, COOPER C. Epidemiology of sarcopenia and insight into possible therapeutic targets[J/OL].Nature Reviews. Rheumatology,2017,13(6):340-347.
[4] BEARD J R, OFFICER A, DE CARVALHO I A, et al. The World report on ageing and health: a policy framework for healthy ageing[J/OL].Lancet (London, England),2016,387(10033):2145-2154.
[5] Sarcopenia: diagnosis and treatment - PubMed[EB/OL].[2025-01-16].https://pubmed.ncbi.nlm.nih.gov/18615226/.
[6] GLICK D, BARTH S, MACLEOD K F. Autophagy: cellular and molecular mechanisms[J/OL]. The Journal of Pathology, 2010,221(1):3-12.
[7] MIZUSHIMA N,YOSHIMORI T,LEVINE B.Methods in mammali an autophagy research[J/OL].Cell,2010,140(3):313-326.
[8] H Y,T M.Molecular Mechanisms of Macroautophagy, Micro autophagy, and Chaperone-Mediated Autophagy[J/OL]. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2024,91(1)[2024-11-30].https://pubmed.ncbi.nlm.nih.gov/37271546/.
[9] PARZYCH K R, KLIONSKY D J. An overview of autophagy: morphology, mechanism, and regulation[J/OL]. Antioxidants & Redox Signaling,2014,20(3):460-473.
[10] NAKATOGAWA H. Mechanisms governing autophagosome biogenesis[J/OL]. Nature Reviews. Molecular Cell Biology, 2020,21(8):439-458.
[11] LAMARK T,SVENNING S,JOHANSEN T.Regulation of select ive autophagy: the p62/SQSTM1 paradigm[J/OL]. Essays in Biochemistry,2017,61(6):609-624.
[12] Insulin and IGF-1 elicit robust transcriptional regu lation to modulate autophagy in astrocytes - PubMed[EB/OL]. [2025-01-16].https://pubmed.ncbi.nlm.nih.gov/36503893/.
[13] Gomisin N attenuated cerebral ischemia-reperfusion injury through inhibition of autophagy by activating the PI3K/AKT/mTOR pathway-PubMed[EB/OL].[2025-01-16].https:// pubmed.ncbi.nlm.nih.gov/36634381/.
[14] MX L,J Y,Y Q,et al.ESMOLOL PROTECTS AGAINST LPSINDUCED CARDIAC INJURY VIA THE AMPK/mTOR/ULK1 PATHWAY IN RAT[J/OL].Shock(Augusta,Ga.),2023,59(3)[2025-01-16].https://pubmed.ncbi.nlm.nih.gov/36579896/.
[15] XIAO H, HAN B, GUO J, et al. [HTD4010 attenuates myocardial injury in mice with septic cardiomyopathy by promoting autophagy via the AMPK/mTOR signaling pathway] [J/OL]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University,2024,44(3):507-514.
[16] SUN B,OU H, REN F, et al. Propofol inhibited autophagy through Ca2+/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury[J/OL]. Molecular Medicine (Cambridge, Mass.), 2018,24(1):58.
[17] PENG M,YE F, FAN C, et al. Endogenous S100P-mediated autophagy regulates the chemosensitivity of leukemia cells through the p53/AMPK/mTOR pathway[J/OL]. American Journal of Cancer Research,2024,14(3):1121-1138.
[18] ALI T, RAHMAN S U, HAO Q, et al. Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation[J/OL]. Journ al of Pineal Research,2020,69(2):e12667.
[19] ZHENG Y, SHI B, MA M, et al. The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfu sion[J/OL].Journal of Cellular Physiology,2019,234(5):5488-5495.
[20] MASIERO E, AGATEA L, MAMMUCARI C, et al. Autophagy is required to maintain muscle mass[J/OL]. Cell Metabolism, 2009,10(6):507-515.
[21] NEMAZANYY I, BLAAUW B, PAOLINI C, et al. Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopa thy and lysosomal disease[J/OL].EMBO molecular medicine, 2013,5(6):870-890.
[22] CARNIO S, LOVERSO F, BARAIBAR M A, et al. Autophagy impairment in muscle induces neuromuscular junction degen eration and precocious aging[J/OL]. Cell Reports, 2014, 8(5):1509-1521.
[23] COLLIER J J,GUISSART C,OLÁHOVÁ M,et al. Development al Consequences of Defective ATG7-Mediated Autophagy in Humans[J/OL]. The New England Journal of Medicine, 2021,384(25):2406-2417.
[24] SANDRI M. Autophagy in skeletal muscle[J/OL]. FEBS letters,2010, 584(7):1411-1416.
[25] WOHLGEMUTH S E, SEO A Y, MARZETTI E, et al. Skeletal muscle autophagy and apoptosis during aging: effects of calo rie restriction and life-long exercise[J/OL]. ExperimentalGerontology,2010,45(2):138-148.
[26] DRUMMOND M J,ADDISON O,BRUNKER L,et al. Downregulat ion of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison[J/OL]. The Journals of Gerontolo gy. Series A, Biological Sciences and Medical Sciences, 2014, 69(8):1040-1048.
[27] RUSS D W,BOYD I M, MCCOY K M, et al. Muscle-specificity of age-related changes in markers of autophagy and sphing olipid metabolism[J/OL].Biogerontology,2015,16(6):747-759.
[28] LI C, WHITE S H, WARREN L K, et al. Skeletal muscle from aged American Quarter Horses shows impairments in mitochon drial biogenesis and expression of autophagy markers[J/OL]. Experimental Gerontology, 2018,102:19-27.
[29] FRY C S, DRUMMOND M J, GLYNN E L, et al. Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults[J/OL]. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences,2013,68(5):599-607.
[30] The satellite cell in skeletal muscle: A story of heterogeneity-PubMed[EB/OL].[2025-01-16].https://pubmed.ncbi.nlm.nih.gov/38670703/.
[31] CHEN W, CHEN Y, LIU Y, et al. Autophagy in muscle regeneration:potential therapies for myopathies[J/OL]. Jour nal of Cachexia, Sarcopenia and Muscle,2022,13(3):1673-1685.
[32] WHITE J P,BILLIN A N,CAMPBELL M E,et al.The AMPK/p27 Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells[J/OL]. Stem Cell Reports, 2018,11(2):425-439.
[33] GARCÍA-PRAT L,MARTÍNEZ-VICENTE M,PERDIGUERO E, et al.Autophagy maintains stemness by preventing senescence[J/OL].Nature, 2016, 529(7584):37-42.
[34] Geriatric muscle stem cells switch reversible quies cence into senescence-PubMed[EB/OL].[2025-01-16].https:// pubmed.ncbi.nlm.nih.gov/24522534/.
[35] TANG A H, RANDO T A. Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation[J/OL]. The EMBO journal,2014,33(23):2782-2797.
[36] BAECHLER B L,BLOEMBERG D,QUADRILATERO J. Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation[J/OL]. Autoph agy,2019,15(9):1606-1619.
[37] REZUŞ E, BURLUI A, CARDONEANU A, et al. Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age [J/OL]. International Journal of Molecular Sciences, 2020,21(2):592.
[38] LI C W, YU K, SHYH-CHANG N, et al. Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention[J/OL]. Journal of Cachexia, Sarcopenia and Muscle,2019,10(3):586-600.
[39] Reactive oxygen species: impact on skeletal muscle -PubMed[EB/OL].[2025-01-16].https://pubmed.ncbi.nlm.nih.gov /23737208/.
[40] BIASIZZO M, KOPITAR-JERALA N. Interplay Between NLRP3 Inflammasome and Autophagy[J/OL].Frontiers in Immunol ogy, 2020,11:591803.
[41] HOU G Z, GUO Q, HAN P P. [Autophagy Activation and Mitochondrial Quality Control in Sarcopenia][J/OL]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 2022,44(4):709-716.
[42] JACQUEL A, OBBA S, BOYER L, et al. Autophagy is required for CSF-1-induced macrophagic differentiation andacquisition of phagocytic functions[J/OL]. Blood, 2012, 119 (19): 4527-4531.
[43] Impaired macrophage autophagy induces systemic insulin resistance in obesity - PubMed[EB/OL]. [2025-01-16].https://pubmed.ncbi.nlm.nih.gov/27229537/.
[44] VAN DER POL A, VAN GILST W H, VOORS A A, et al. Treating oxidative stress in heart failure: past, present and future [J/OL].European Journal of Heart Failure,2019,21(4):425-435.
[45] ZHANG H, QI G, WANG K, et al. Oxidative stress: Roles in skeletal muscle atrophy[J/OL]. Biochemical Pharmacology, 2023,214:115664.
[46] KINOSHITA H, ORITA S, INAGE K, et al. Skeletal Muscle Cell Oxidative Stress as a Possible Therapeutic Target in a Denervation-Induced Experimental Sarcopenic Model[J/OL]. Spine,2019,44(8):E446-E455.
[47] ABRIGO J, SIMON F, CABRERA D, et al. Mitochondrial Dysfunction in Skeletal Muscle Pathologies[J/OL]. Current Protein & Peptide Science,2019,20(6):536-546.
[48] LIU B Y, LI L, LIU G L, et al. Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes[J/OL]. Acta Pharm acologica Sinica,2021,42(5):701-714.
[49] WANG H H, SUN Y N, QU T Q, et al. Nobiletin Prevents D-Galactose-Induced C2C12 Cell Aging by Improving Mitocho ndrial Function[J/OL]. International Journal of Molecular Scie nces,2022,23(19):11963.
[50] SARRAF S A, SIDERIS D P, GIAGTZOGLOU N, et al. PINK1 /Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis[J/OL]. Cell Reports, 2019,29(1):225-235.e5.
[51] WHITE Z,TERRILL J, WHITE R B,et al. Erratum to: Volunt ary resistance wheel exercise from mid-life prevents sarcope nia and increases markers of mitochondrial function and auto phagy in muscles of old male and female C57BL/6J mice[J/OL]. Skeletal Muscle,2017,7(1):4.
[52] ZENG Z,LIANG J,WU L,et al.Exercise-Induced Autophagy Suppresses Sarcopenia Through Akt/mTOR and Akt/FoxO3a Signal Pathways and AMPK-Mediated Mitochondrial Quality Control[J/OL]. Frontiers in Physiology,2020,11:583478.
[53] VAINSHTEIN A, GRUMATI P, SANDRI M, et al. Skeletal muscle, autophagy, and physical activity: the ménage à trois of metabolic regulation in health and disease[J/OL]. Journal of Molecular Medicine (Berlin, Germany),2014,92(2):127-137.
[54] PRYDE K R, SMITH H L, CHAU K Y, et al. PINK1 disables the anti-fission machinery to segregate damaged mitochond ria for mitophagy[J/OL]. The Journal of Cell Biology, 2016, 213(2):163-171.
[55] ABREU P, MENDES S V D, CECCATTO V M, et al. Satellite cell activation induced by aerobic muscle adaptation in response to endurance exercise in humans and rodents[J/OL]. Life Sciences,2017,170:33-40.
[56] XIE W Q, XIAO W F, TANG K, et al. Caloric restriction: implications for sarcopenia and potential mechanisms[J/OL]. Aging,2020,12(23):24441-24452.
[57] BAKER D J, BETIK A C, KRAUSE D J, et al. No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: effects are independent of mitochondrial DNA integrity[J/OL].The Journals of Gerontolo gy. Series A, Biological Sciences and Medical Sciences, 2006,61(7):675-684.
[58] NING Y C, CAI G Y, ZHUO L, et al. Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage[J/OL]. Mechanisms of Ageing and Development, 2013,134(11-12):570-579.
[59] VAN NORREN K, RUSLI F, VAN DIJK M, et al. Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice[J/OL]. Journal of Cachexia, Sarcopenia and Muscle,2015,6(3):253-268.
[60] SZAFRANSKI K, MEKHAIL K. The fine line between lifesp an extension and shortening in response to caloric restricti on[J/OL].Nucleus (Austin,Tex.),2014,5(1):56-65.
[61] BOSTRÖM P,WU J,JEDRYCHOWSKI M P,et al.A PGC1-α- dependent myokine that drives brown-fat-like development of white fat and thermogenesis[J/OL]. Nature, 2012, 481(7382): 463-468.
[62] ROCA-RIVADA A,CASTELAO C,SENIN L L,et al.FNDC5/iris in is not only a myokine but also an adipokine[J/OL]. PloS One,2013,8(4):e60563.
[63] ZHANG H,WU X,LIANG J,et al.Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process[J/OL].Ageing Research Reviews,2022, 80: 101680.
[64] REZA M M, SUBRAMANIYAM N, SIM C M, et al. Irisin is a pro-myogenic factor that induces skeletal muscle hypertro phy and rescues denervation-induced atrophy[J/OL]. Nature Communications,2017,8(1):1104.
[65] MEN X M, XU Z W, TAO X, et al. FNDC5 expression closely correlates with muscle fiber types in porcine longissimus dorsi muscle and regulates myosin heavy chains (MyHCs) mRNA expression in C2C12 cells[J/OL]. PeerJ,2021,9:e11065.
[66] XIN T, LU C. Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myoca rdial infarction[J/OL]. Aging,2020,12(5):4474-4488.
[67] RYU D, MOUCHIROUD L, ANDREUX P A, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents[J/OL]. Nature Medicine, 2016,22(8):879-888.
[68] ANDREUX P A,BLANCO-BOSE W,RYU D,et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans[J/OL].Nature Metabolism,2019,1(6):595-603.
[69] EISENBERG T,ABDELLATIF M,SCHROEDER S,et al.Cardiopr otection and lifespan extension by the natural polyamine spermidine[J/OL]. Nature Medicine,2016,22(12):1428-1438.
[70] ZHA W, SUN Y, GONG W, et al. Ginseng and ginsenosides: Therapeutic potential for sarcopenia[J/OL]. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2022, 156: 113876.
[71] KIM T J, PYUN D H, KIM M J, et al. Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppre ssion of endoplasmic reticulum stress[J/OL].Journal of Ginse ng Research,2022,46(3):444-453.
[2] CRUZ-JENTOFT A J,BAHAT G, BAUER J, et al. Sarcopenia: revised European consensus on definition and diagnosis[J/OL]. Age and Ageing,2019,48(4):601.
[3] DENNISON E M, SAYER A A, COOPER C. Epidemiology of sarcopenia and insight into possible therapeutic targets[J/OL].Nature Reviews. Rheumatology,2017,13(6):340-347.
[4] BEARD J R, OFFICER A, DE CARVALHO I A, et al. The World report on ageing and health: a policy framework for healthy ageing[J/OL].Lancet (London, England),2016,387(10033):2145-2154.
[5] Sarcopenia: diagnosis and treatment - PubMed[EB/OL].[2025-01-16].https://pubmed.ncbi.nlm.nih.gov/18615226/.
[6] GLICK D, BARTH S, MACLEOD K F. Autophagy: cellular and molecular mechanisms[J/OL]. The Journal of Pathology, 2010,221(1):3-12.
[7] MIZUSHIMA N,YOSHIMORI T,LEVINE B.Methods in mammali an autophagy research[J/OL].Cell,2010,140(3):313-326.
[8] H Y,T M.Molecular Mechanisms of Macroautophagy, Micro autophagy, and Chaperone-Mediated Autophagy[J/OL]. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2024,91(1)[2024-11-30].https://pubmed.ncbi.nlm.nih.gov/37271546/.
[9] PARZYCH K R, KLIONSKY D J. An overview of autophagy: morphology, mechanism, and regulation[J/OL]. Antioxidants & Redox Signaling,2014,20(3):460-473.
[10] NAKATOGAWA H. Mechanisms governing autophagosome biogenesis[J/OL]. Nature Reviews. Molecular Cell Biology, 2020,21(8):439-458.
[11] LAMARK T,SVENNING S,JOHANSEN T.Regulation of select ive autophagy: the p62/SQSTM1 paradigm[J/OL]. Essays in Biochemistry,2017,61(6):609-624.
[12] Insulin and IGF-1 elicit robust transcriptional regu lation to modulate autophagy in astrocytes - PubMed[EB/OL]. [2025-01-16].https://pubmed.ncbi.nlm.nih.gov/36503893/.
[13] Gomisin N attenuated cerebral ischemia-reperfusion injury through inhibition of autophagy by activating the PI3K/AKT/mTOR pathway-PubMed[EB/OL].[2025-01-16].https:// pubmed.ncbi.nlm.nih.gov/36634381/.
[14] MX L,J Y,Y Q,et al.ESMOLOL PROTECTS AGAINST LPSINDUCED CARDIAC INJURY VIA THE AMPK/mTOR/ULK1 PATHWAY IN RAT[J/OL].Shock(Augusta,Ga.),2023,59(3)[2025-01-16].https://pubmed.ncbi.nlm.nih.gov/36579896/.
[15] XIAO H, HAN B, GUO J, et al. [HTD4010 attenuates myocardial injury in mice with septic cardiomyopathy by promoting autophagy via the AMPK/mTOR signaling pathway] [J/OL]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University,2024,44(3):507-514.
[16] SUN B,OU H, REN F, et al. Propofol inhibited autophagy through Ca2+/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury[J/OL]. Molecular Medicine (Cambridge, Mass.), 2018,24(1):58.
[17] PENG M,YE F, FAN C, et al. Endogenous S100P-mediated autophagy regulates the chemosensitivity of leukemia cells through the p53/AMPK/mTOR pathway[J/OL]. American Journal of Cancer Research,2024,14(3):1121-1138.
[18] ALI T, RAHMAN S U, HAO Q, et al. Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation[J/OL]. Journ al of Pineal Research,2020,69(2):e12667.
[19] ZHENG Y, SHI B, MA M, et al. The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfu sion[J/OL].Journal of Cellular Physiology,2019,234(5):5488-5495.
[20] MASIERO E, AGATEA L, MAMMUCARI C, et al. Autophagy is required to maintain muscle mass[J/OL]. Cell Metabolism, 2009,10(6):507-515.
[21] NEMAZANYY I, BLAAUW B, PAOLINI C, et al. Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopa thy and lysosomal disease[J/OL].EMBO molecular medicine, 2013,5(6):870-890.
[22] CARNIO S, LOVERSO F, BARAIBAR M A, et al. Autophagy impairment in muscle induces neuromuscular junction degen eration and precocious aging[J/OL]. Cell Reports, 2014, 8(5):1509-1521.
[23] COLLIER J J,GUISSART C,OLÁHOVÁ M,et al. Development al Consequences of Defective ATG7-Mediated Autophagy in Humans[J/OL]. The New England Journal of Medicine, 2021,384(25):2406-2417.
[24] SANDRI M. Autophagy in skeletal muscle[J/OL]. FEBS letters,2010, 584(7):1411-1416.
[25] WOHLGEMUTH S E, SEO A Y, MARZETTI E, et al. Skeletal muscle autophagy and apoptosis during aging: effects of calo rie restriction and life-long exercise[J/OL]. ExperimentalGerontology,2010,45(2):138-148.
[26] DRUMMOND M J,ADDISON O,BRUNKER L,et al. Downregulat ion of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison[J/OL]. The Journals of Gerontolo gy. Series A, Biological Sciences and Medical Sciences, 2014, 69(8):1040-1048.
[27] RUSS D W,BOYD I M, MCCOY K M, et al. Muscle-specificity of age-related changes in markers of autophagy and sphing olipid metabolism[J/OL].Biogerontology,2015,16(6):747-759.
[28] LI C, WHITE S H, WARREN L K, et al. Skeletal muscle from aged American Quarter Horses shows impairments in mitochon drial biogenesis and expression of autophagy markers[J/OL]. Experimental Gerontology, 2018,102:19-27.
[29] FRY C S, DRUMMOND M J, GLYNN E L, et al. Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults[J/OL]. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences,2013,68(5):599-607.
[30] The satellite cell in skeletal muscle: A story of heterogeneity-PubMed[EB/OL].[2025-01-16].https://pubmed.ncbi.nlm.nih.gov/38670703/.
[31] CHEN W, CHEN Y, LIU Y, et al. Autophagy in muscle regeneration:potential therapies for myopathies[J/OL]. Jour nal of Cachexia, Sarcopenia and Muscle,2022,13(3):1673-1685.
[32] WHITE J P,BILLIN A N,CAMPBELL M E,et al.The AMPK/p27 Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells[J/OL]. Stem Cell Reports, 2018,11(2):425-439.
[33] GARCÍA-PRAT L,MARTÍNEZ-VICENTE M,PERDIGUERO E, et al.Autophagy maintains stemness by preventing senescence[J/OL].Nature, 2016, 529(7584):37-42.
[34] Geriatric muscle stem cells switch reversible quies cence into senescence-PubMed[EB/OL].[2025-01-16].https:// pubmed.ncbi.nlm.nih.gov/24522534/.
[35] TANG A H, RANDO T A. Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation[J/OL]. The EMBO journal,2014,33(23):2782-2797.
[36] BAECHLER B L,BLOEMBERG D,QUADRILATERO J. Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation[J/OL]. Autoph agy,2019,15(9):1606-1619.
[37] REZUŞ E, BURLUI A, CARDONEANU A, et al. Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age [J/OL]. International Journal of Molecular Sciences, 2020,21(2):592.
[38] LI C W, YU K, SHYH-CHANG N, et al. Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention[J/OL]. Journal of Cachexia, Sarcopenia and Muscle,2019,10(3):586-600.
[39] Reactive oxygen species: impact on skeletal muscle -PubMed[EB/OL].[2025-01-16].https://pubmed.ncbi.nlm.nih.gov /23737208/.
[40] BIASIZZO M, KOPITAR-JERALA N. Interplay Between NLRP3 Inflammasome and Autophagy[J/OL].Frontiers in Immunol ogy, 2020,11:591803.
[41] HOU G Z, GUO Q, HAN P P. [Autophagy Activation and Mitochondrial Quality Control in Sarcopenia][J/OL]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 2022,44(4):709-716.
[42] JACQUEL A, OBBA S, BOYER L, et al. Autophagy is required for CSF-1-induced macrophagic differentiation andacquisition of phagocytic functions[J/OL]. Blood, 2012, 119 (19): 4527-4531.
[43] Impaired macrophage autophagy induces systemic insulin resistance in obesity - PubMed[EB/OL]. [2025-01-16].https://pubmed.ncbi.nlm.nih.gov/27229537/.
[44] VAN DER POL A, VAN GILST W H, VOORS A A, et al. Treating oxidative stress in heart failure: past, present and future [J/OL].European Journal of Heart Failure,2019,21(4):425-435.
[45] ZHANG H, QI G, WANG K, et al. Oxidative stress: Roles in skeletal muscle atrophy[J/OL]. Biochemical Pharmacology, 2023,214:115664.
[46] KINOSHITA H, ORITA S, INAGE K, et al. Skeletal Muscle Cell Oxidative Stress as a Possible Therapeutic Target in a Denervation-Induced Experimental Sarcopenic Model[J/OL]. Spine,2019,44(8):E446-E455.
[47] ABRIGO J, SIMON F, CABRERA D, et al. Mitochondrial Dysfunction in Skeletal Muscle Pathologies[J/OL]. Current Protein & Peptide Science,2019,20(6):536-546.
[48] LIU B Y, LI L, LIU G L, et al. Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes[J/OL]. Acta Pharm acologica Sinica,2021,42(5):701-714.
[49] WANG H H, SUN Y N, QU T Q, et al. Nobiletin Prevents D-Galactose-Induced C2C12 Cell Aging by Improving Mitocho ndrial Function[J/OL]. International Journal of Molecular Scie nces,2022,23(19):11963.
[50] SARRAF S A, SIDERIS D P, GIAGTZOGLOU N, et al. PINK1 /Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis[J/OL]. Cell Reports, 2019,29(1):225-235.e5.
[51] WHITE Z,TERRILL J, WHITE R B,et al. Erratum to: Volunt ary resistance wheel exercise from mid-life prevents sarcope nia and increases markers of mitochondrial function and auto phagy in muscles of old male and female C57BL/6J mice[J/OL]. Skeletal Muscle,2017,7(1):4.
[52] ZENG Z,LIANG J,WU L,et al.Exercise-Induced Autophagy Suppresses Sarcopenia Through Akt/mTOR and Akt/FoxO3a Signal Pathways and AMPK-Mediated Mitochondrial Quality Control[J/OL]. Frontiers in Physiology,2020,11:583478.
[53] VAINSHTEIN A, GRUMATI P, SANDRI M, et al. Skeletal muscle, autophagy, and physical activity: the ménage à trois of metabolic regulation in health and disease[J/OL]. Journal of Molecular Medicine (Berlin, Germany),2014,92(2):127-137.
[54] PRYDE K R, SMITH H L, CHAU K Y, et al. PINK1 disables the anti-fission machinery to segregate damaged mitochond ria for mitophagy[J/OL]. The Journal of Cell Biology, 2016, 213(2):163-171.
[55] ABREU P, MENDES S V D, CECCATTO V M, et al. Satellite cell activation induced by aerobic muscle adaptation in response to endurance exercise in humans and rodents[J/OL]. Life Sciences,2017,170:33-40.
[56] XIE W Q, XIAO W F, TANG K, et al. Caloric restriction: implications for sarcopenia and potential mechanisms[J/OL]. Aging,2020,12(23):24441-24452.
[57] BAKER D J, BETIK A C, KRAUSE D J, et al. No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: effects are independent of mitochondrial DNA integrity[J/OL].The Journals of Gerontolo gy. Series A, Biological Sciences and Medical Sciences, 2006,61(7):675-684.
[58] NING Y C, CAI G Y, ZHUO L, et al. Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage[J/OL]. Mechanisms of Ageing and Development, 2013,134(11-12):570-579.
[59] VAN NORREN K, RUSLI F, VAN DIJK M, et al. Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice[J/OL]. Journal of Cachexia, Sarcopenia and Muscle,2015,6(3):253-268.
[60] SZAFRANSKI K, MEKHAIL K. The fine line between lifesp an extension and shortening in response to caloric restricti on[J/OL].Nucleus (Austin,Tex.),2014,5(1):56-65.
[61] BOSTRÖM P,WU J,JEDRYCHOWSKI M P,et al.A PGC1-α- dependent myokine that drives brown-fat-like development of white fat and thermogenesis[J/OL]. Nature, 2012, 481(7382): 463-468.
[62] ROCA-RIVADA A,CASTELAO C,SENIN L L,et al.FNDC5/iris in is not only a myokine but also an adipokine[J/OL]. PloS One,2013,8(4):e60563.
[63] ZHANG H,WU X,LIANG J,et al.Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process[J/OL].Ageing Research Reviews,2022, 80: 101680.
[64] REZA M M, SUBRAMANIYAM N, SIM C M, et al. Irisin is a pro-myogenic factor that induces skeletal muscle hypertro phy and rescues denervation-induced atrophy[J/OL]. Nature Communications,2017,8(1):1104.
[65] MEN X M, XU Z W, TAO X, et al. FNDC5 expression closely correlates with muscle fiber types in porcine longissimus dorsi muscle and regulates myosin heavy chains (MyHCs) mRNA expression in C2C12 cells[J/OL]. PeerJ,2021,9:e11065.
[66] XIN T, LU C. Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myoca rdial infarction[J/OL]. Aging,2020,12(5):4474-4488.
[67] RYU D, MOUCHIROUD L, ANDREUX P A, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents[J/OL]. Nature Medicine, 2016,22(8):879-888.
[68] ANDREUX P A,BLANCO-BOSE W,RYU D,et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans[J/OL].Nature Metabolism,2019,1(6):595-603.
[69] EISENBERG T,ABDELLATIF M,SCHROEDER S,et al.Cardiopr otection and lifespan extension by the natural polyamine spermidine[J/OL]. Nature Medicine,2016,22(12):1428-1438.
[70] ZHA W, SUN Y, GONG W, et al. Ginseng and ginsenosides: Therapeutic potential for sarcopenia[J/OL]. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2022, 156: 113876.
[71] KIM T J, PYUN D H, KIM M J, et al. Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppre ssion of endoplasmic reticulum stress[J/OL].Journal of Ginse ng Research,2022,46(3):444-453.
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