纳米药物递送系统在眼科的应用与发展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i1.11803
Abstract
眼部解剖结构的特殊性和多种生理屏障(如角膜、血-视网膜屏障等)的存在是导致药物眼内生物利用度低,治疗效果差的重要原因之一。促进药物眼内转运,提高眼内有效药物浓度和延长药物作用时间是改善眼病药物治疗效果亟需攻克的难关。随着药学、材料学和生物医学等多种学科的交叉融合,“新型药物递送系统”这一概念应运而生。其中,基于纳米技术开发的药物递送载体,可显著提高药物的转运能力、靶向性和安全性等,为眼病的药物治疗带来新的机遇。
Keywords
新型药物递送系统;纳米技术;眼部用药
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[32] PARSAEI M, AKHBARI K, TYLIANAKIS E, et al. Effects of Fluorinated Functionalization of Linker on Quercetin Encaps ulation, Release and Hela Cell Cytotoxicity of Cu-Based MOFs as Smart pH-Stimuli Nanocarriers[J]. Chemistry, 2024, 30(1):e202301630.
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[3] GUIMARãES D, CAVACO-PAULO A and NOGUEIRA E. Design of liposomes as drug delivery system for therapeutic appli cations[J].Int J Pharm,2021,601:120571.
[4] DATTA D, PRIYANKA BANDI S, COLACO V, et al. Fostering the unleashing potential of nanocarriers-mediated delivery of ocular therapeutics[J].Int J Pharm,2024,658:124192.
[5] QU F, SUN Y, BI D, et al. Regulating Size and Charge of Liposomes in Microneedles to Enhance Intracellular Drug Deli very Efficiency in Skin for Psoriasis Therapy[J]. Adv Healthc Mater,2023,12(31):e2302314.
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[7] SPLEIS H, SANDMEIER M, CLAUS V, et al. Surface design of nanocarriers: Key to more efficient oral drug delivery syst ems[J].Adv Colloid Interface Sci,2023,313:102848.
[8] SHIMOKAWA T,FUKUTA T, INAGI T, et al. Protective effect of high-affinity liposomes encapsulating astaxanthin against corneal disorder in the in vivo rat dry eye disease model[J]. J Clin Biochem Nutr,2020,66(3):224-232.
[9] LV Y,ZHAI C,SUN G,et al.Chitosan as a promising mater ials for the construction of nanocarriers for diabetic retinop athy:an updated review[J].J Biol Eng,2024,18(1):18.
[10] BADRAN MM, ALOMRANI AH, ALMOMEN A, et al. Novel Metoprolol-Loaded Chitosan-Coated Deformable Liposomes in Thermosensitive In Situ Gels for the Management of Glaucoma: A Repurposing Approach[J].Gels,2022,8(10): 635.
[11] DOS SANTOS GA, FERREIRA-NUNES R, DALMOLIN LF, et al. Besifloxacin liposomes with positively charged additives for an improved topical ocular delivery[J]. Sci Rep, 2020, 10(1):19285.
[12] ZHANG Y,ZHOU T,WANG K,et al. Corneal Mucin-Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation[J].Adv Sci (Weinh), 2024):e2411172.
[13] CANATO E, GRIGOLETTO A, ZANOTTO I, et al. Anti-HER2 Super Stealth Immunoliposomes for Targeted-Chemotherapy [J].Adv Healthc Mater,2023,12(29):e2301650.
[14] SAADH MJ,MUSTAFA MA,KUMAR A,et al.Stealth Nanocarr iers in Cancer Therapy:a Comprehensive Review of Design, Func tionality, and Clinical Applications[J]. AAPS PharmSciTech, 2024,25(6):140.
[15] KIAIE SH, MAJIDI ZOLBANIN N, AHMADI A, et al. Recent advances in mRNA-LNP therapeutics:immunological and pharma cological aspects[J].J Nanobiotechnology,2022,20(1):276.
[16] MIRJALILI MOHANNA SZ, DJAKSIGULOVA D, HILL AM, et al. LNP-mediated delivery of CRISPR RNP for wide-spread in vivo genome editing in mouse cornea[J]. J Control Release, 2022, 350:401-413.
[17] WANG Y, LI H, RASOOL A, et al. Polymeric nanoparticles (PNPs)for oral delivery of insulin[J]. J Nanobiotechnology, 2024,22(1):1.
[18] ROCHA CV, GONçALVES V, DA SILVA MC, et al. PLGA-Based Composites for Various Biomedical Applications[J]. Int J Mol Sci,2022,23(4):2034.
[19] BAO H,TIAN Y,WANG H,et al. Exosome-loaded degradable polymeric microcapsules for the treatment of vitreoretinal diseases[J].Nat Biomed Eng,2024,8(11):1436-1452.
[20] ALOTAIBI H, HATAHET T and AL-JAMAL WT. Indocyanine green J-aggregate (IJA)theranostics:Challenges and opportu nities[J].Int J Pharm,2024,661:124456.
[21] LIU F, CHEN Y, LI Y, et al. Folate-receptor-targeted laser-activable poly(lactide-co-glycolic acid) nanoparticles loaded with paclitaxel/indocyanine green for photoacoustic/ ultrasound imaging and chemo/photothermal therapy[J]. Int J Nanomedicine,2018,13:5139-5158.
[22] JAFERNIK K,ŁADNIAK A,BLICHARSKA E,et al. ChitosanBased Nanoparticles as Effective Drug Delivery Systems-A review[J].Molecules,2023,28(4):1963.
[23] CHAIYASAN W, PRAPUTBUT S,KOMPELLA UB,et al. Penetrat ion of mucoadhesive chitosan-dextran sulfate nanoparticles into the porcine cornea[J].Colloids Surf B Biointerfaces, 2017,149:288-296.
[24] HASSAN H, ALI AI, ELDESAWY EM, et al. Pharmacokinetic and Pharmacodynamic Evaluation of Gemifloxacin Chitosan Nanoparticles As an Antibacterial Ocular Dosage Form[J]. J Pharm Sci,2022,111(5):1497-1508.
[25] ALBARQI HA, GARG A, AHMAD MZ, et al. Recent Progress in Chitosan-Based Nanomedicine for Its Ocular Application in Glaucoma[J].Pharmaceutics,2023,15(2): 681.
[26] PANDIT J,SULTANA Y and AQIL M.Chitosan coated nanopa rticles for efficient delivery of bevacizumab in the posterior ocular tissues via subconjunctival administration[J]. Carboh ydr Polym,2021,267:118217.
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[28] SUN Z,LI T,MEI T,et al. Nanoscale MOFs in nanomedicine applications: from drug delivery to therapeutic agents[J]. J Mater Chem B,2023,11(15):3273-3294.
[29] TANG Y, HAN Y, ZHAO J, et al. A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns [J].Nanomicro Lett,2023,15(1):112.
[30] LI B,ASHRAFIZADEH M and JIAO T.Biomedical applicati on of metal-organic frameworks (MOFs) in cancer therapy: Stimuli-responsive and biomimetic nanocomposites in targe ted delivery, phototherapy and diagnosis[J]. Int J Biol Macro mol,2024,260(Pt 2):129391.
[31] LIU S, DONG J, FANG X, et al. Nanoscale Zinc-Based Metal-Organic Frameworks Induce Neurotoxicity by Disturbing the Metabolism of Catecholamine Neurotransmitters[J]. Envir on Sci Technol, 2023, 57(13): 5380-5390.
[32] PARSAEI M, AKHBARI K, TYLIANAKIS E, et al. Effects of Fluorinated Functionalization of Linker on Quercetin Encaps ulation, Release and Hela Cell Cytotoxicity of Cu-Based MOFs as Smart pH-Stimuli Nanocarriers[J]. Chemistry, 2024, 30(1):e202301630.
[33] CHOI W and KOHANE DS. Hybrid Nanoparticle-Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applic ations[J].ACS Nano,2024,18(34):22780-22792.
[34] LIU YC, LIN YK, LIN YT, et al. Injectable, Antioxidative, and Tissue-Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries[J]. Adv Sci (Weinh), 2024, 11(11):e2308635.
[35] LEE S, HONG HK, SONG JS, et al. Intravitreal injectable hydrogel rods with long-acting bevacizumab delivery to the retina[J].Acta Biomater,2023,171:273-288.
[36] XEROUDAKI M, RAFAT M,MOUSTARDAS P,et al.A doublecrosslinked nanocellulose-reinforced dexamethasone-loaded collagen hydrogel for corneal application and sustained anti-inflammatory activity[J].Acta Biomater,2023,172:234-248.
[37] ZHOU Y, ZHAO C, SHI Z, et al. A Glucose-Responsive Hydrogel Inhibits Primary and Secondary BRB Injury for Retinal Microenvironment Remodeling in Diabetic Retinopathy [J].Adv Sci (Weinh),2024,11(32):e2402368.
[38] CHEN Y and FENG X. Gold nanoparticles for skin drug delivery[J].Int J Pharm,2022,625:122122.
[39] HAASE A,MIROSCHNIKOV N,KLEIN S,et al.New retinoblast oma(RB) drug delivery approaches: anti-tumor effect of atrial natriuretic peptide (ANP)-conjugated hyaluronic-acid-coated gold nanoparticles for intraocular treatment of chemoresista nt RB[J].Mol Oncol,2024,18(4):832-849.
[40] ALHOWYAN AA, KALAM MA, IQBAL M, et al. Mesoporous Silica Nanoparticles Coated with Carboxymethyl Chitosan for 5-Fluorouracil Ocular Delivery: Characterization, In Vitro and In Vivo Studies[J].Molecules,2023,28(3):1260.
[41] PAIVA MRB, ANDRADE GF, DOURADO LFN, et al. Surface functionalized mesoporous silica nanoparticles for intravitr eal application of tacrolimus[J]. J Biomater Appl, 2021, 35(8):1019-1033.
[42] WU M, WANG S, WANG Y, et al. Targeted delivery of mitomycin C-loaded and LDL-conjugated mesoporous silica nanoparticles for inhibiting the proliferation of pterygium subconjunctival fibroblasts[J].Exp Eye Res,2020,197:108124.
[43] AMATO R,GIANNACCINI M,DAL MONTE M, et al. Association of the Somatostatin Analog Octreotide With Magnetic Nanopar ticles for Intraocular Delivery: A Possible Approach for the Treatment of Diabetic Retinopathy[J]. Front Bioeng Biotech nol,2020,8:144.
[44] BASSETTO M, AJOY D, POULHES F, et al. Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice[J].Pharmaceutics,2021,13(10):1650.
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