翼状胬肉的 p53 和 TGF-β表达及相关联系
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i1.11798
Abstract
目的：评估抑癌基因p53蛋白和转化生长因子β(TGF-β)在翼状胬肉中的表达,并探讨它们之间的关系。方法：在20例翼状胬肉、10例正常结膜的研究样本中,进行组织蜡块包埋切片,使用免疫组织化学染色的方法观察p53和TGF-β的表达。结果：在我们的研究中,45%翼状胬肉标本的p53表达呈阳性;40%翼状胬肉标本TGF-β染色呈阳性;所有正常结膜均未显示p53或TGF-β染色。翼状胬肉组的p53和TGF-β反应性均大于正常结膜组(P<0.05)。Fisher精确检验分析证实了TGF-β与p53表达之间存在高度统计学意义的相关性(P<0.05)。结论：p53和TGF-β翼状胬肉中过表达,它们之间存在相关性。
Keywords
翼状胬肉；TGF-β；p53
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[1] DETORAKIS E T,SPANDIDOS D A. Pathogenetic mechanisms and treatment options for ophthalmic pterygium: trends and perspectives (Review)[J].Int J Mol Med,2009,23(4):439-47.
[2] BRADLEY J C, YANG W, BRADLEY R H, et al. The science of pterygia[J].Br J Ophthalmol,2010,94(7):815-20.
[3] MULLER P A, VOUSDEN K H, NORMAN J C. p53 and its mutants in tumor cell migration and invasion [J]. J Cell Biol, 2011,192(2):209-18.
[4] TSAI Y Y,CHANG K C,LIN C L,et al.p53 Expression in pter ygium by immunohistochemical analysis: a series report of 127 cases and review of the literature[J].Cornea,2005,24(5):583-6.
[5] KHALFAOUI T,MKANNEZ G,COLIN D,et al.Immunohistochemi cal analysis of vascular endothelial growth factor (VEGF) and p53 expression in pterygium from Tunisian patients[J]. Pathol Biol (Paris),2011,59(3):137-41.
[6] TSAI Y Y, CHENG Y W, LEE H, et al. P53 gene mutation spectrum and the relationship between gene mutation and protein levels in pterygium[J].Mol Vis,2005,11:50-5.
[7] CHOWERS I,PE'ER J, ZAMIR E, et al. Proliferative activity and p53 expression in primary and recurrent pterygia [J]. Ophthalmology,2001,108(5):985-8.
[8] ISAJI M, KIKUCHI S, MIYATA H, et al. Inhibitory effects of tranilast on the proliferation and functions of human pterygium-derived fibroblasts[J].Cornea,2000,19(3):364-8.
[9] PANG Y, ROSE T.Rapid growth of pterygium after photo refractive keratectomy[J].Optometry,2006,77(10):499-502.
[10] DI GIROLAMO N,WAKEFIELD D,CORONEO M T.UVB-mediated induction of cytokines and growth factors in pterygium epith elial cells involves cell surface receptors and intracellular signaling[J].Invest Ophthalmol Vis Sci,2006,47(6):2430-7.
[11] EROĞUL Ö, ŞEN S. Comparison of Biomarkers Playing a Role in Pterygium Development in Pterygium and Recurrent Pterygium Tissues[J].Diagnostics(Basel),2024,14(23).
[12] PERRA M T, MAXIA C, CORBU A, et al. Oxidative stress in pterygium:relationship between p53 and 8-hydroxydeoxygu anosine[J].Mol Vis,2006,12:1136-42.
[13] NIU X, XU C, CHEUK Y C, et al. Characterizing hub biomarkers for post-transplant renal fibrosis and unveiling their immunological functions through RNA sequencing and advanced machine learning techniques[J].Journal of Transla tional Medicine,2024,22(1).
[14] BRADLEY P,THOMAS P G.Using T Cell Receptor Repertoi res to Understand the Principles of Adaptive Immune Recognit ion[J].Annual Review of Immunology,2019,37(1):547-70.
[15] FANG Y, SHEN B, DAI Q, et al. Composition and diversity analysis of the TCR CDR3 repertoire in patients with idiopa thic orbital inflammation using high-throughput sequencing [J].BMC Ophthalmology,2023,23(1).
[16] KRIA L,OHIRA A,AMEMIYA T.Immunohistochemical locali zation of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-beta and tumor necrosis factor-alpha in the pterygium[J].Acta Histochem, 1996, 98(2):195-201.
[17] DETORAKIS E T, ZARAVINOS A, SPANDIDOS D A. Growth fac tor expression in ophthalmic pterygia and normal conjunctiva [J].Int J Mol Med,2010,25(4):513-6.
[2] BRADLEY J C, YANG W, BRADLEY R H, et al. The science of pterygia[J].Br J Ophthalmol,2010,94(7):815-20.
[3] MULLER P A, VOUSDEN K H, NORMAN J C. p53 and its mutants in tumor cell migration and invasion [J]. J Cell Biol, 2011,192(2):209-18.
[4] TSAI Y Y,CHANG K C,LIN C L,et al.p53 Expression in pter ygium by immunohistochemical analysis: a series report of 127 cases and review of the literature[J].Cornea,2005,24(5):583-6.
[5] KHALFAOUI T,MKANNEZ G,COLIN D,et al.Immunohistochemi cal analysis of vascular endothelial growth factor (VEGF) and p53 expression in pterygium from Tunisian patients[J]. Pathol Biol (Paris),2011,59(3):137-41.
[6] TSAI Y Y, CHENG Y W, LEE H, et al. P53 gene mutation spectrum and the relationship between gene mutation and protein levels in pterygium[J].Mol Vis,2005,11:50-5.
[7] CHOWERS I,PE'ER J, ZAMIR E, et al. Proliferative activity and p53 expression in primary and recurrent pterygia [J]. Ophthalmology,2001,108(5):985-8.
[8] ISAJI M, KIKUCHI S, MIYATA H, et al. Inhibitory effects of tranilast on the proliferation and functions of human pterygium-derived fibroblasts[J].Cornea,2000,19(3):364-8.
[9] PANG Y, ROSE T.Rapid growth of pterygium after photo refractive keratectomy[J].Optometry,2006,77(10):499-502.
[10] DI GIROLAMO N,WAKEFIELD D,CORONEO M T.UVB-mediated induction of cytokines and growth factors in pterygium epith elial cells involves cell surface receptors and intracellular signaling[J].Invest Ophthalmol Vis Sci,2006,47(6):2430-7.
[11] EROĞUL Ö, ŞEN S. Comparison of Biomarkers Playing a Role in Pterygium Development in Pterygium and Recurrent Pterygium Tissues[J].Diagnostics(Basel),2024,14(23).
[12] PERRA M T, MAXIA C, CORBU A, et al. Oxidative stress in pterygium:relationship between p53 and 8-hydroxydeoxygu anosine[J].Mol Vis,2006,12:1136-42.
[13] NIU X, XU C, CHEUK Y C, et al. Characterizing hub biomarkers for post-transplant renal fibrosis and unveiling their immunological functions through RNA sequencing and advanced machine learning techniques[J].Journal of Transla tional Medicine,2024,22(1).
[14] BRADLEY P,THOMAS P G.Using T Cell Receptor Repertoi res to Understand the Principles of Adaptive Immune Recognit ion[J].Annual Review of Immunology,2019,37(1):547-70.
[15] FANG Y, SHEN B, DAI Q, et al. Composition and diversity analysis of the TCR CDR3 repertoire in patients with idiopa thic orbital inflammation using high-throughput sequencing [J].BMC Ophthalmology,2023,23(1).
[16] KRIA L,OHIRA A,AMEMIYA T.Immunohistochemical locali zation of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-beta and tumor necrosis factor-alpha in the pterygium[J].Acta Histochem, 1996, 98(2):195-201.
[17] DETORAKIS E T, ZARAVINOS A, SPANDIDOS D A. Growth fac tor expression in ophthalmic pterygia and normal conjunctiva [J].Int J Mol Med,2010,25(4):513-6.
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