咽喉反流与耳鼻喉科疾病相关性的研究进展

Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i5.10115

钱妍融, 张英

青海大学附属医院耳鼻咽喉科

Abstract

咽喉反流性疾病(Laryngopharyngeal Reflux Disease,LPRD)是耳鼻喉科的常见病,大量数据表明,LPRD在中国耳鼻喉头颈外科(Otolaryngology Head and Neck Surgery,OHNS)诊所的发病率呈持续升高趋势。最近关于咽喉反流在影响上呼吸消化道上皮的病理状况发展中的意义正不断被重视。部分学者认为其只是胃食管反流病(Gastroesophageal Reflux Disease,GERD)的食管外表现。随着对LPRD研究的深入,越来越多的学者认为它是一种独立疾病,并且是一种多因素综合征,GERD并不是其发病的唯一原因。关于咽喉反流的发病机制及其与耳鼻喉科疾病的相关性,仍有很多需要了解的地方。因此,了解咽喉反流的发病机制,明确其与耳鼻喉科疾病的相关性,对LPRD患者开展积极的诊治具有十分重要的意义。

Keywords

咽喉反流;耳鼻咽喉科;发病机制

References

[1] KOUFMAN J A,AVIV J E,CASIANO R R,etal.Laryngopharyn geal reflux: position statement of the committee on speech, voice, and swallowing disorders of the American Academy of Otolaryngology-Head and Neck Surgery [J]. Otolaryngol Head Neck Surg,2002,127(1):32-5.
[2] LECHIEN J R.Clinical Update Findings about pH-Imped ance Monitoring Features in Laryngopharyngeal Reflux Patients [J].J Clin Med,2022,11(11).
[3] MASSAWE W A,NKYA A,ABRAHAM Z S,etal.Laryngopharyngeal reflux disease, prevalence and clinical characteristics in ENT department of a tertiary hospital Tanzania[J].World J Otorhin olaryngol Head Neck Surg,2021,7(1):28-33.
[4] XIAO S, LI J, ZHENG H, et al. An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology -head and neck surgery clinics in China[J].Eur Arch Otorhinol aryngol,2020,277(10):2829-38.
[5] Lenderking W R, Hillson E, Crawley J A,etal. The clinical characteristics and impact of laryngopharyngeal reflux disea se on health‐related quality of life[J]. Value in Health, 2003, 6(5):560-565.
[6] Locke 3rd G R, Talley N J, Fett S L, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a populat ion-based study in Olmsted County,Minnesota[J].Gastroenter ology,1997,112(5):1448-1456.
[7] 龚齐,周康年.反流性咽喉炎与胃食管反流病的关系研究[J].临床耳鼻咽喉科杂志,2001(12):548-549.
[8] ORIDATE N, TAKEDA H, YAMAMOTO J, et al. Helicobacter pylori seropositivity predicts outcomes of acid suppression therapy for laryngopharyngeal reflux symptoms[J].Laryngos cope,2006,116(4): 547-53.
[9] De Bortoli N, Nacci A, Savarino E, et al. How many cases of laryngopharyngeal reflux suspected by laryngoscopy aregastroesophageal reflux disease-related?[J]. World journal of gastroenterology:WJG,2012,18(32):4363.
[10] Sataloff R T. Laryngopharyngeal reflux: concepts and controversies[J].Ear,Nose & Throat Journal,2008,87(10):549-554.
[11] HAMMER H F.Reflux-associated laryngitis and laryng opharyngeal reflux: a gastroenterologist's point of view [J]. Dig Dis,2009,27(1):14-7.
[12] JOHNSTON N, KNIGHT J, DETTMAR P W, et al. Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease[J].Laryngoscope,2004,114 (12):2129-34.
[13] BARDHAN K D,STRUGALA V,DETTMAR P W. Reflux revisited: advancing the role of pepsin [J]. Int J Otolaryngol, 2012, 2012: 646901.
[14] LI J, WANG J, WU M, et al. The role of nonacid reflux in laryngopharyngeal reflux diseases[J].Eur Arch Otorhinolar yngol,2020,277(10):2813-9.
[15] Galli J, Calo L, Agostino S, et al. Bile reflux as possible risk factor in laryngo-pharyngeal inflammatory and neoplastic lesions[J].Acta otorhinolaryngologica italica, 2003,23(5):377-382.
[16] SASAKI C T, DOUKAS S G, COSTA J, et al. Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications[J].Cancer,2019,125(20):3554-65.
[17] FARROKHI F,VAEZI M F.Extra-esophageal manifestatio ns of gastroesophageal reflux[J].Oral Dis,2007,13(4):349-59.
[18] DIAZ VICO T,ELLI E F.Clinical outcomes of gastroeso phageal reflux disease-related chronic cough following antir eflux fundoplication[J].Esophagus,2020,17(1):92-8.
[19] REN Q W, LEI G, ZHAO Y L, et al. Laryngopharyngeal Reflux and Benign Vocal Fold Lesions: A Systematic Review and Meta-analysis[J].Otolaryngol Head Neck Surg,2023.
[20] 朱虹,徐文,李赟,等.声带白斑临床病理特征与咽喉反流的初步观察[J].中华耳鼻咽喉头颈外科杂志,2014(5):368-373.
[21] GONG X,WANG X Y,YANG L,etal.Detecting Laryngopharyn geal Reflux by Immunohistochemistry of Pepsin in the Biopsi es of Vocal Fold Leukoplakia[J].J Voice,2018,32(3):352-5.
[22] PARSEL S M, WU E L, RILEY C A, et al. Gastroesophageal and Laryngopharyngeal Reflux Associated With Laryngeal Malignancy: A Systematic Review and Meta-analysis [J]. Clin Gastroenterol Hepatol,2019,17(7):1253-64e5.
[23] CONNOR N P, PALAZZI-CHURAS K L, COHEN S B, et al. Symptoms of extraesophageal reflux in a community-dwelling sample[J].J Voice,2007,21(2):189-202.
[24] 吴彦桥,梁芳芳.咽喉反流性鼻炎的临床初步研究[J].临床耳鼻咽喉头颈外科杂志,2016,30(3):200-202.
[25] DAGLI E, YUKSEL A, KAYA M, et al. Association of Oral Antireflux Medication With Laryngopharyngeal Reflux and Nasal Resistance[J].JAMA Otolaryngol Head Neck Surg,2017,143 (5):478-83.
[26] DELGAUDIO J M.Direct nasopharyngeal reflux of gast ric acid is a contributing factor in refractory chronic rhinosinusitis[J].Laryngoscope,2005,115(6):946-57.
[27] DiBaise J K, Olusola B F, Huerter J V, et al. Role of GERD in chronic resistant sinusitis: a prospective, open label,pilot trial[J].The American journal of gastroenterology, 2002, 97(4):843-850.
[28] VELEPIC M M,VELEPIC M S,STARCEVIC R,etal.Gastroesoph ageal reflux and sequelae of chronic tubotympanal disorders in children[J].Acta Otolaryngol,2004,124(8):914-7.
[29] Tasker A, Dettmar P W, Panetti M, et al. Is gastric reflux a cause of otitis media with effusion in children?[J]. The Laryngoscope,2002,112(11):1930-1934.
[30] SONE M, YAMAMURO Y, HAYASHI H, et al. Otitis media in adults as a symptom of gastroesophageal reflux[J].Otolaryngol Head Neck Surg,2007,136(1):19-22.
[31] ABD EL-FATTAH A M, ABDUL MAKSOUD G A, RAMADAN A S, et al. Pepsin assay: a marker for reflux in pediatric glue ear[J].Otolaryngol Head Neck Surg,2007,136(3):464-70.
[32] HAN H,LV Q.Characteristics of laryngopharyngeal refl ux in patients with chronic otitis media [J]. Am J Otolaryngol,2018,39(5):493-6.
[33] VILIUSYTE E,MACAITYTE R,VAITKUS A, et al. Associations between peripheral vertigo and gastroesophageal reflux disease [J].MedHypotheses,2015,85(3):333-5.
[34] 曹雅晨,张瑾,张文.耳鸣与咽喉反流相关性研究进展[J].听力学及言语疾病杂志,2021,29(02):226-228.
[35] ERYILMAZ A, ERISEN L, DEMIR U L, et al. Management of patients with coexisting obstructive sleep apnea and laryngo pharyngeal reflux disease[J].Eur Arch Otorhinolaryngol,2012,269(12):2575-80.
[36] KURIBAYASHI S,MASSEY B T, HAFEEZULLAH M, et al. Upper esophageal sphincter and gastroesophageal junction pressure changes act to prevent gastroesophageal and esophagopharyng eal reflux during apneic episodes in patients with obstructive sleep apnea[J].Chest,2010,137(4):769-76.

Copyright © 2024 钱妍融, 张英

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License