高原脑水肿血脑屏障损伤的研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i5.10112
Abstract
急性高原病(acute mountain sickness,AMS)是指个体迅速暴露于高海拔环境(通常在2500米以上)或者从高海拔进入更高海拔地区时,由于低氧环境下体内氧气供应不足导致的综合征。高原脑水肿(high altitude cerebral edema,HACE)被认为是AMS发展的终末结果,其主要特征是由于低氧环境引发的脑水肿和血脑屏障(blood brain barrier,BBB)损伤。随着高原病研究的深入,越来越多的文献报道了与HACE相关的分子机制,了解这些分子在HACE发病过程中的角色,将为未来的研究提供重要基础。为此,本文旨在综述当前研究中涉及的主要相关基因,从而为深入探讨HACE的发生机制提供参考。
Keywords
高原脑水肿；血脑屏障；分子机制；研究进展
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[21] Zhao Y,Gan L,Ren L,etal.Factors influencing the blood -brain barrier permeability[J].Brain research,2022,1788:147937.
[22] Branca J J V, Maresca M, Morucci G, et al. Effects of cadmium on ZO-1 tight junction integrity of the blood brain barrier[J]. International journal of molecular sciences, 2019, 20(23):6010.
[23] Nitta T,Hata M,Gotoh S,et al. Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice[J]. The Journal of cell biology,2003,161(3):653-660.
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