异常凝血酶原预测肝癌微血管侵犯的价值研究
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i5.10093
Abstract
目的:探讨肝细胞癌(hepatocellularcarcinoma,HCC)发生微血管侵犯(MVI)的影响因素及研究血清异常凝血酶原(PIVKA-II)预测HCC发生MVI的价值;方法 回顾性分析湖南省人民医院2020-01-01至2024-03-31行手术治疗且病理结果为HCC的126例患者的临床资料。按照是否发生MVI分为MVI阴性组(60例)和MVI阳性组(66例)。收集患者基本信息及术前的病理、影像学、PIVKA-Ⅱ、甲胎蛋白、血常规、肝功能、凝血功能等指标,采用单因素及多因素Logistic回归探讨HCC出现MVI的影响因素,且根据受试者工作曲线(ROC)研究PIVKA-Ⅱ预测HCC发生MVI的价值。结果 (1)通过单因素分析发现:白细胞、凝血酶原时间、血小板、总胆红素、甲胎蛋白、异常凝血酶原、肿瘤最大径、肿瘤个数差异具有统计学意义(P<0.05);(2)多因素Logistic回归分析发现:PIVKA-II(OR=2.001,P=0.007)为HCC患者发生MVI的独立危险因素;(3)ROC曲线分析发现:PIVKA-Ⅱ诊断MVI的曲线下面积(AUC)、灵敏度、特异度和截断值分别为0.935、86%、87%、270.15mAU/ml。结论(1)PIVKA-II大于270.15mAU/ml是HCC出现MVI的独立危险因素。(2)PIVKA-II预测HCC出现MVI有良好的价值。
Keywords
异常凝血酶原;肝细胞癌;微血管侵犯
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[1] Peng,Liu,Qinghe,Tang,Miaomiao,Chen etal.Hepatocellular Senescence:Immunosurveillance and Future Senescence-Induc ed Therapy in Hepatocellular Carcinoma.[J] .Front Oncol, 2020,10(0):589-908.
[2] Seehofer D,Sucher R,Denecke T.Resection and transplan tation for hepatocellular carcinoma and intrahepatic cholangiocarcinoma[J].Radiologe,2022,62(3):210-218.
[3] Ma XL,Zhu J,Wu J,et al. Significance of PIVKA-II levels for predicting microvascular invasion and tumor cell prolif eration in Chinese patients with hepatitis B virus associated hepatocellular carcinoma[J].Oncol Lett,2018,15(6):8396-8404.
[4] LI H,LI T,HU J,etal.A nomogram to predict microvascular invasion in early hepatocellular carcinoma[J]. J Cancer Res Therap,2021,17(3):652.
[5] 国家卫生健康委员会医政医管局.原发性肝癌诊疗规范(2019年版)[J].中国实用外科杂志,2020,40(2):121-138.
[6] LINWD,YELN,SONGZS,etal.Wide surgical margins improve prognosis for HCC with microvascular invasion[J]. Eur Rev Med Pharmacol Sci,2023,27(5):2052-2059.
[7] 郑华珍,雷秋成,陈展泽,等.异常凝血酶原联合甲胎蛋白预测肝细胞癌微血管侵犯的价值研究[J].国际检验医学杂志,2024,45(7):790-793.
[8] 周小泉,赵凯亮,王卫星.肝细胞癌微血管侵犯术前预测因素及价值探讨[j].微循环学杂志,2023,33(2):55-60.
[9] 何涛.探讨异常凝血酶原对肝癌微血管侵犯和预后的预测价值[D].西南医科大学,2020.
[10] 蒋传林.术前NLR,血清AFP联合异常凝血酶原对肝细胞癌微血管侵犯的预测分析[D].广西医科大学,2022.
[2] Seehofer D,Sucher R,Denecke T.Resection and transplan tation for hepatocellular carcinoma and intrahepatic cholangiocarcinoma[J].Radiologe,2022,62(3):210-218.
[3] Ma XL,Zhu J,Wu J,et al. Significance of PIVKA-II levels for predicting microvascular invasion and tumor cell prolif eration in Chinese patients with hepatitis B virus associated hepatocellular carcinoma[J].Oncol Lett,2018,15(6):8396-8404.
[4] LI H,LI T,HU J,etal.A nomogram to predict microvascular invasion in early hepatocellular carcinoma[J]. J Cancer Res Therap,2021,17(3):652.
[5] 国家卫生健康委员会医政医管局.原发性肝癌诊疗规范(2019年版)[J].中国实用外科杂志,2020,40(2):121-138.
[6] LINWD,YELN,SONGZS,etal.Wide surgical margins improve prognosis for HCC with microvascular invasion[J]. Eur Rev Med Pharmacol Sci,2023,27(5):2052-2059.
[7] 郑华珍,雷秋成,陈展泽,等.异常凝血酶原联合甲胎蛋白预测肝细胞癌微血管侵犯的价值研究[J].国际检验医学杂志,2024,45(7):790-793.
[8] 周小泉,赵凯亮,王卫星.肝细胞癌微血管侵犯术前预测因素及价值探讨[j].微循环学杂志,2023,33(2):55-60.
[9] 何涛.探讨异常凝血酶原对肝癌微血管侵犯和预后的预测价值[D].西南医科大学,2020.
[10] 蒋传林.术前NLR,血清AFP联合异常凝血酶原对肝细胞癌微血管侵犯的预测分析[D].广西医科大学,2022.
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