91种炎症蛋白与胆道癌发病风险的因果关系
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i5.10088
Abstract
背景：胆道恶性肿瘤(BTC)是一种极为恶性的肿瘤,其5年生存率通常低于5%。炎症在BTC的发病机制中扮演重要角色,但目前关于炎症与BTC之间的因果关系研究仍较为匮乏。目的：本研究旨在通过两样本双向孟德尔随机化分析,评估炎症相关蛋白与BTC之间的潜在因果关系。方法：我们使用GWAS数据中的遗传变异(SNP)作为工具变量,依据关联性、独立性和排他性假设筛选有效的工具变量。炎症相关蛋白的数据来源于GWAS Catalog(包含14824名欧洲人),而BTC的数据则来自IEU数据库(包括196084名东亚人)。工具变量筛选标准为SNP阈值P<5×10-8,排除连锁不平衡影响,F统计量>10。分析采用R软件包,包括IVW法、WM法和MR-Egger回归等方法。敏感性分析通过Cochran's Q统计量检验异质性,并使用MR-Egger回归和MR-PRESSO评估水平多效性。结果：我们发现7种炎症相关蛋白与BTC存在显著的因果关系,其中4种为BTC的危险因素,包括CD40L受体、成纤维细胞生长因子23(FGF23)、胶质细胞源性神经营养因子(GDNF)和白介素7(IL-7)；另外3种为BTC的保护因素,包括神经生长因子β(β-NGF)、S100A12蛋白(S100-A12)和γ干扰素(INFγ)。结论：这些发现对于深入理解BTC的发病机制及其预防和治疗策略具有重要指导意义。
Keywords
孟德尔随机化；炎症相关蛋白；胆道恶性肿瘤；GWAS数据；因果关系
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[26] 孟令新,丁兆军,陈希平,等.神经生长因子促进MIAPaCa-2人胰腺癌细胞的增殖[J].中国肿瘤生物治疗杂志,2010,17(1):88-92.
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