股骨颈骨折动力交叉钉与其他固定的荟萃分析

Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i5.10055

宗驿1, 丰哲2, 莫万瑜1, 袁阳1, 周天豪1, 邹建斌1

1. 广西中医药大学研究生院
2. 广西中医药大学附属瑞康医院

Abstract

目的:综合评价股骨颈动力交叉钉系统固定与其他固定方式治疗股骨颈骨折的效果。方法:计算机检索PubMed、Embase、Cochrane Library、Web of science、CNKI、万方、维普数据库,同时手动检索中华医学会系列期刊的相关文献,检索时间为自建库至2022年5月。汇总所有关于股骨颈动力交叉钉系统固定与其他内固定治疗股骨颈骨折的对照研究,纳入条件相符合的文章,并逐一对纳入研究进行严格评价的文献质量评价。采取RevMan 5.4软件进行本次的Meta分析。纳入的指标包含手术时长、住院时长、术中出血量、术中透视次数、手术切口长度、骨折愈合时间、末次Harris评分、股骨头坏死发生率、骨不连发生率以及股骨颈短缩发生率。结果:共纳入23篇文献,其中中文文献14篇,英文文献9篇,纳入研究文献共1036例股骨颈骨折患者,其中476例使用股骨颈动力交叉钉系统固定,560例采用其他内固定方式。Meta分析结果显示,与其他内固定方式相比,股骨颈动力交叉钉系统具有骨折愈合时间短 [SMD=-0.46,95%CI(-0.63,-0.29),P<0.00001]、末次Harris评分高[SMD=0.62,95%CI(0.48,0.77),P<0.00001]、股骨颈短缩发生率低[OR=0.45,95%CI(0.26,0.77),P=0.003],但术中出血量多[SMD=0.32,95%CI(0.15,0.48),P=0.0001],在住院时长[SMD=0.02,95%CI(–0.13,-0.17),P=0.82]、股骨坏死发生率[SMD=0.52,95%CI(0.27,1.02),P=0.06]、骨不连发生率[OR=0.55,95%CI(0.30,1.00),P=0.05]方面二者无差异。手术时长、术中透视次数由于异质性较大,所以采用描述性分析,需进一步的研究证明差异性。手术切口长度由于研究未能提供详细的数据,所以也采用描述性分析,需进一步的研究证明差异性。结论:与其他内固定相比,股骨颈动力交叉钉系统固定骨折愈合时间短、末次Harris评分高、股骨颈短缩发生率低,但术中出血量多,在住院时长、股骨坏死发生率、骨不连发生率方面无差异。

Keywords

股骨颈骨折;股骨颈动力交叉钉系统固定;Meta分析

Funding

广西壮族自治区科技重大专项(医疗机构中药制剂开发)桂科AA23023035-2。

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