阴道微生态失衡与HPV感染及宫颈病变关系
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i4.8524
Abstract
宫颈癌是妇女常见的恶性肿瘤之一,严重威胁着妇女的生命安全。人乳头瘤病毒(human papillomavirus,HPV)是影响宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)和宫颈癌的重要因素。而阴道微生态环境作为女性生殖道健康的第一道防线,也可影响生殖道疾病的发生和发展。研究认为,阴道微生态失衡与HPV的感染率和CIN的风险密切相关。本研究回顾了近年来有关阴道微生态功能与形态变化与HPV感染及CIN的相关文献内容并进行综述。
Keywords
阴道微生态；人乳头瘤病毒；宫颈上皮内瘤变；宫颈癌
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[3] KUMARI S,BHORVM. Association of cervicovaginal dysbio sis mediated HPV infection with cervical intraepithelial neopl asia[J].Microb Pathogenesis,2021,152:104780.
[4] 廖秦平.阴道微生态评价的临床应用专家共识[J].中华妇产科杂志,2016,51(10):721-723.
[5] Tucker KM, Godha K, Mirkin S,et al. Vaginal pH: a simple assessment highly correlated with vaginal morphology and symptoms in postmenopausal women[J].Menopause.2018;25(7): 762-766.
[6] Farage M, Maibach H. Lifetime changes in the vulva and vagina[J].Arch Gynecol Obstet.2006;273(4):195-202.
[7] García-Closas M,Herrero R,Bratti C,etal. Epidemiologic determinants of vaginal pH[J].Am J Obstet Gynecol.1999;180 (5):1060-1066.
[8] Liu Y,Li Z.Vaginal pH value can affect the susceptibil ity to human papillomavirus infection[J]. BMC Infect Dis. 2024 Feb 9;24(1):176.
[9] Clarke MA, Rodriguez AC, Gage JC,et al. A large, popula tion-based study of age-related associations between vagin al pH and human papillomavirus infection[J]. BMC Infect Dis. 2012 Feb 8;12:33.
[10] Gillet E,Meys JF, Verstraelen H,et al. Bacterial vagino sis is associated with uterine cervical human papillomavirus infection: a meta-analysis[J].BMC Infect Dis.2011 Jan 11;11:10.
[11] Josey WE, Lambe DW Jr. Epidemiologic characteristics of women infected with Corynebacterium vaginale (Haemophil us vainalis)[J].J Am Vener Dis Assoc.1976 Sep;3(1):9-13.
[12] Dahoud W, Michael CW, Gokozan H,et al. A. Association of Bacterial Vaginosis and Human Papilloma Virus Infection With Cervical Squamous Intraepithelial Lesions[J]. Am J Clin Pathol.2019 Jul5;152(2):185-189.
[13] Morris M, Nicoll A, Simms I,et al. Bacterial vaginosis: a public health review[J].BJOG.2001May;108(5):439-50.
[14] Doerflinger SY, Throop AL, Herbst-Kralovetz MM. Bact eria in the vaginal microbiome alter the innate immune resp onse and barrier properties of the human vaginal epithelia in a species-specific manner[J].J Infect Dis.2014 Jun 15;209(12):1989-99.
[15] Anton L, Ferguson B, Friedman ES,et al. Gardnerella vaginalis alters cervicovaginal epithelial cell function thro ugh microbe-specific immune responses[J].Microbiome. 2022 Aug 4;10(1):119.
[16] Yang X, Da M, Zhang W,et al. Role of Lactobacillus in cervical cancer. Cancer Manag Res.2018 May 16;10:1219-1229.
[17] 张娴,王世军,周莲娥,等.阴道微生态环境与人乳头瘤病毒感染的相关性分析[J].中国病案,2023,24(10):104-107.
[18] Liang Y, Chen M, Qin L,et al. A meta-analysis of the relationship between vaginal microecology, human papilloma virus infection and cervical intraepithelial neoplasia[J]. Infect Agent Cancer.2019Oct26;14:29.
[19] Wang X, Coleman HN, Nagarajan U,et al. Candida skin test reagent as a novel adjuvant for a human papillomavirus peptide-based therapeutic vaccine[J]. Vaccine.2013;31(49): 5806-5813.
[20] Hamar B, Teutsch B, Hoffmann E,et al. Trichomonas vagi nalis infection is associated with increased risk of cervical carcinogenesis: A systematic review and meta-analysis of 470 000 patients[J].Int J Gynaecol Obstet.2023Oct;163(1):31-43.
[21] 王和舒琦,白会会,刘朝晖.妇科门诊患者阴道微生态特征及其与人乳头瘤病毒感染的相关性分析[J].中国实用妇科与产科杂志,2023,39(2):226-230.
[22] Zhong H, Tong Y, Lin H,et al. Coinfection of High-Risk Human Papillomavirus and Lower Genital Tract Pathogens in the Development of High-Grade Cervical Lesions.Can J Infect Dis Med Microbiol. 2020;2020:7640758. Published 2020 Aug 30.
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