急性呼吸窘迫综合征发病机制的研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i4.8520
Abstract
急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是一种临床较为常见的肺部疾病,主要是由于肺部炎症或非心源性水肿导致的以顽固性低氧及呼吸困难为主的临床表现的一组综合征,病因可分为肺内因素(直接因素)和肺外因素(间接因素)。ARDS是一种综合征诊断,而不是一种独特的病理实体,因此ARDS 具有很大的异质性。该研究从ARDS发病机制出发,旨在尽早干预肺内外各种因素导致急性呼吸窘迫综合征等方面的研究提供参考。
Keywords
急性呼吸窘迫综合征；诊断标准；病理生理学机制；内皮素-1；细胞外囊泡；肾素-血管紧张素系统；信号通路
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[2] Batah SS, Fabro AT. Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians. Respir Med. 2021 Jan;176:106239. doi: 10.1016/j.rmed.2020.106239. Epub 2020 Nov19.PMID:33246294; PMCID:PMC7674971.
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[4] Imai Y,Kuba K,Neely G G,etal.Identification of Oxidat ive Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute LungInjury[J].Cell,2008,133(2):235-249.
[5] Vichare, Riddhi.,Janjic,Jelena M..Macrophage-Targeted Nanomedicines for ARDS/ALI: Promise and Potential.Inflammation,2022.
[6] A M M,G H F,Christine C .Lung epithelial fluid transport and the resolution of pulmonary edema.[J].Physiological revie ws,2002,82(3):569-600.
[7] Sadis M ,Rafal B ,FJ C.Role of epithelial sodium chann els in the regulation of lung fluid homeostasis.[J].American journal of physiology. Lung cellular and molecular physiology,2015,309(11):L1229-38.
[8] 封珊,王云鹏,成翕悦,等.急性呼吸窘迫综合征患者血浆内皮素-1浓度变化的分析[J].中华麻醉学杂志,2023,43(4):441-444.
[9] El Sayed M, Sherif L, Said RN, El-Wakkad AS, El-Refay A, Aly H. Endothelin-1 and L-arginine in preterm infants with respiratory distress. Am J Perinatol. 2011 Feb;28(2):129-36.doi:10.1055/s-0030-1263295IF:1.5Q2. Epub 2010 Aug 10. PMID:20700864.
[10] Chih-Chung L,Wei-Ning L,Wei-Chen H,et al.Endothelin -1induces VCAM-1 expression-mediated inflammation via re ceptor tyrosine kinases and Elk/p300 in human tracheal smooth muscle cells.[J].American journal of physiology. Lung cellular and molecular physiology,2015,309(3):L211-25.
[11] Xiong R,Lu X,Song J,Li H, Wang S. Molecular mechanisms of hydrogen sulfide against uremic accelerated atherosclero sis through cPKCβII/Akt signal pathway. BMC Nephrol. 2019 Sep 14;20(1):358.doi:10.1186/s12882-01915504IF:2.2Q2.PMID:31521120;PMCID:PMC6744675.
[12] 祁梦雷,刘维英,刘茹悦,等.细胞外囊泡在急性呼吸窘迫综合征中的研究进展[J].中国呼吸与危重监护杂志,2021,20(5):372-375.
[13] Heedoo L,Duo Z,L D L,etal.Functional Evidence of Pulm onary Extracellular Vesicles in Infectious and Noninfectious Lung Inflammation.[J].Journal of immunology (Baltimore, Md. : 1950),2018,201(5):1500-1509.
[14] Merit R ,Nancy M ,Gerardo G , et al.beta1 and beta2 integrins activate different signalling pathways in monocytes. [J].Biochemicaljournal,2002,363(Pt 2):273-80.
[15] 彭李娜,何军华.肾素-血管紧张素系统在急性呼吸窘迫综合征发病机制中的重要作用探讨[J].中国全科医学,2023,26(S1):109-113.
[16] Batah SS, Fabro AT. Pulmonary pathology of ARDS in COVID-19:A pathological review for clinicians.RespirMed.2021Jan;176:106239.doi:10.1016/j.rmed.2020.106239IF:3.5Q2.Epub 2020 Nov 19. PMID: 33246294; PMCID: PMC7674971.
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