LN-5在调控结合上皮附着机制中的效应述解
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i4.8518
Abstract
结合上皮(junctional epithelial,JE)角蛋白-19呈强阳性,缺乏K6和K16,与口腔上皮不同。本文综述JE附着机制中层粘连蛋白的作用和内外基质的组成。JE通过内外侧基质附着于牙面和牙龈结缔组织上。内侧基质由透明致密的板块组成,在化学和结构上与外侧基质不同。内侧基质缺乏IV型胶原和LN-1,只含有层粘连蛋白-5(laminin-5,LN-5),这种分子是JE基底板中的一种大分子糖蛋白,能诱导半桥粒形成并促进细胞粘附,促进上皮细胞的附着与增殖。本文介绍了LN体系及其分子链结构,并阐述LN-5在JE基质中的生物学等功能及作用机制,述解了LN-5在JE基质中的生物学等功能。
Keywords
结合上皮；内外侧基板；层粘连蛋白-5；上皮附着；基底膜；半粒体；整合素；牙种植体
Funding
(1)浙江省教育厅一般科研项目(专业学位研究生培养模式改革专项)浙江大学科研项目资助(XY2022050)AProject Supported by Scientific Research Fund of Zhejiang University；(2)浙江大学医学院附属口腔医院院内探索课题5022270；(3)浙江省科技厅分析测试公益性项目LGC22H140001；(4)浙江大学双一流《新时代思想政治教育创新计划》2021年本科生(2-2050205-21-005)；(5)浙江大学医学院教育改革课题yxyb20172030。
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[2] Shimono,M.,Ishikawa, T.,Enokiya,Y.,Muramatsu,T.,Matsuzaka, K.,Inoue,T.,Abiko,Y.,Yamaza,T.,Kido,M.A.,Tanaka,T.,& Hashimoto,S. (2003).Biological characteristics of the junctional epithelium.Journal of electron microscopy,52(6),627-639.
[3] Fujii, N., Kusakari, H., & Maeda, T. (1998). A histological study on tissue responses to titanium implantation in rat maxilla:the process of epithelial regeneration and bone react ion.Journal of periodontology,69(4),485-495.
[4] Atsuta,I.,Yamaza,T., Yoshinari, M., Mino, S., Goto, T., Kido, M.A.,Terada,Y.,& Tanaka,T.(2005). Changes in the distribution of laminin-5during peri-implant epithelium formation after immediate titanium implantation in rats.Biomaterials,26(14), 1751-1760.
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[7] Tanaka, K.,Tanaka, J.,Aizawa, R.etal.Structure of juncti onal epithelium is maintained by cell populations supplied from multiple stem cells.Sci Rep 11,18860(2021).
[8] Yuan, X.,Chen, J., Grauer, J. A., Xu, Q., Van Brunt, L. A., & Helms, J. A. (2021). The Junctional Epithelium Is Maintained by a Stem Cell Population. Journal of dental research,100(2), 209-216.
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[16] Mulla,S.A.,Patil,A., Mali, S., Jain, A., Sharma, D., Jaiswal, H.C.,Saoji,H.A.,Jakhar,A.,Talekar,S., & Singh, S. (2023). Exploring the Biological Width in Dentistry: A Comprehensive Narrative Review.Cureus,15(7),e42080.
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[18] Steflik, D. E., McKinney, R. V., Jr, & Koth, D. L. (1988).Epithelial attachment to ceramic dental implants.Annals of the New York Academy of Sciences,523,4-18.
[19] 陈东晖,黄海云&丁一.层粘连蛋白-5结构及功能的研究进展[J].国际口腔医学杂志,2007(03),181-184.
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[21] Tamura,R. N., Oda, D., Quaranta, V., Plopper, G., Lambert, R., Glaser, S., & Jones, J. C.(1997). Coating of titanium alloywith soluble laminin-5 promotes cell attachment and hemide smosome assembly in gingival epithelial cells: potential appl ication to dental implants.Journal of periodontal research, 32(3),287-294.
[22] Aellos,F.,Grauer,J.A., Harder, K. G., Dworan, J. S., Fabbri, G., Cuevas, P. L., Yuan, X., Liu, B., Brunski, J. B., & Helms, J. A. (2024). Dynamic analyses of a soft tissue-implant interface: Biological responses to immediate versus delayed dental implants.Journal of clinical periodontology,51(7), 806-817.
[23] Baker, S. E., Hopkinson, S. B., Fitchmun, M., Andreason, G. L., Frasier, F., Plopper, G., Quaranta, V., & Jones, J. C. (1996). Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly.Journal of cell science,109(Pt10),2509-2520.
[24] Atsuta,I.,Yamaza,T.,Yoshinari,M.,Goto,T.,Kido,M.A.,Kagiya,T., Mino, S., Shimono, M., & Tanaka, T. (2005). Ultrastructural localization of laminin-5(gamma2 chain)in the rat peri-impla nt oral mucosa around a titanium-dental implant by immuno -electron microscopy.Biomaterials,26(32),6280-6287.
[25] Hormia,M.,Sahlberg,C.,Thesleff, I., & Airenne, T. (1998). The epithelium-tooth interface--a basal lamina rich in laminin -5 and lacking other known laminin isoforms.Journal of dental research,77(7),1479-1485.
[26] Hohenester E.(2019).Structural biology of laminins. Essays in biochemistry,63(3),285-295.
[27] Mizushima, H., Koshikawa, N., Moriyama, K., Takamura, H., Nagashima,Y.,Hirahara,F.,& Miyazaki,K.(1998). Wide distributionof laminin-5 gamma 2 chain in basement membranes of various human tissues.Hormone research,50 Suppl2,7-14.
[28] Oksanen,J.,& Hormia, M. (2002). An organotypic in vitro model that mimics the dento-epithelial junction.Journal of periodontology,73(1),86-93.
[29] Driemel, O.,Dahse,R.,Hakim, S. G., Tsioutsias, T., Pistner,H., Reichert,T.E.,& Kosmehl,H.(2007).Laminin-5 immunocytoche mistry: a new tool for identifying dysplastic cells in oral brush biopsies.Cytopathology : official journal of the British Society for Clinical Cytology,18(6),348-355.
[30] Goldfinger,L.E.,Stack,M.S.,&Jones,J.C.(1998).Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator.The Journal of cell biology,141(1),255-265.
[31] Hormia,M.,Owaribe,K.,& Virtanen,I.(2001).The dentoepithelial junction: cell adhesion by type I hemidesmosomes in the absence of a true basal lamina. Journal of periodo ntology,72(6),788-797.
[32] Haas, M., Berndt, A., Hyckel, P., Stiller, K. J., & Kosmehl, H.(2000).Laminin-5 bei Erkrankungen der Mundhöhle [Laminin -5 in diseases of the oral cavity].Mund-,Kiefer-und Gesichts chirurgie:MKG,4(1),25-29.
[33] Dabelsteen,E.,Grøn,B.,Mandel,U., & Mackenzie, I. (1998). Altered expression of epithelial cell surface glycoconjugates and intermediate filaments at the margins of mucosal wounds. The Journal of investigative dermatology,111(4),592-597.
[34] Kainulainen,T.,Hakkinen,L.,Hamidi,S.,Larjava,K.,Kallioinen, M., Peltonen, J., Salo, T., Larjava, H., & Oikarinen, A. (1998). Laminin-5 expression is independent of the injury and the microenvironment during reepithelialization of wounds.Thejournal of histochemistry and cytochemistry: official journal of the Histochemistry Society,46(3),353-360.
[35] Vallée,A.,Faga, M. G., Mussano, F., Catalano, F., Tolosano, E., Carossa,S.,Altruda, F., & Martra, G. (2014). Alumina-zirconia composites functionalized with laminin-1 and laminin-5 for dentistry:effect of protein adsorption on cellular response. Colloids and surfaces.B, Biointerfaces,114,284-293.
[36] Zhang, K., & Kramer, R. H. (1996). Laminin 5 deposition promotes keratinocyte motility.Experimental cell research, 227(2),309-322.
[37] Gürses,N.,Thorup,A.K.,Reibel,J.,Carter,W.G.,&Holmstrup, P.(1999).Expression of VLA-integrins and their related basem ent membrane ligands in gingiva from patients of various periodontitis categories.Journal of clinical periodontology, 26(4),217-224.
[38] Goldfinger,L.E.,Stack,M.S.,& Jones,J.C.(1998).Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator.The Journal of cell biology,141(1),255-265.
[39] Kivelä-Rajamäki, M. J., Teronen, O. P., Maisi, P., Husa, V.,Tervahartiala,T.I.,Pirilä,E.M., Salo, T. A., Mellanen, L., & Sorsa, T.A.(2003).Laminin-5 gamma2-chain and collagenase-2 (MMP-8) in human peri-implant sulcular fluid. Clinical oral implants research,14(2),158-165.
[40] Shimono, M., Ishikawa, T., Enokiya, Y., Muramatsu, T., Matsuzaka, K., Inoue, T., Abiko, Y., Yamaza, T., Kido, M. A., Tanaka, T., & Hashimoto, S.(2003). Biological characteristics of the junctional epithelium.Journal of electron microscopy,52(6),627-639.
[41] Nguyen,B.P.,Gil,S. G., & Carter, W. G. (2000). Deposition of laminin 5 by keratinocytes regulates integrin adhesion and signaling.The Journal of biological chemistry,275(41), 31896 -31907.
[42] Engvall,E.,&Wewer,U.M.(1996).Domains of laminin.Journ al of cellular biochemistry,61(4),493-501.
[43] Oksonen,J.,Sorokin, L. M., Virtanen, & Hormia, M. (2001). The junctional epithelium around murine teeth differs from gingival epithelium in its basement membrane composition. Journal of dental research,80(12),2093-2097.
[44] Masaoka,T., Hashimoto, S., Kinumatsu, T., Muramatsu, T., Jung, H. S., Yamada, S., & Shimono, M. (2009). Immunolocalization of laminin and integrin in regenerating junctional epitheli um of mice after gingivectomy.Journal of periodontal resear ch,44(4),489-495.
[2] Shimono,M.,Ishikawa, T.,Enokiya,Y.,Muramatsu,T.,Matsuzaka, K.,Inoue,T.,Abiko,Y.,Yamaza,T.,Kido,M.A.,Tanaka,T.,& Hashimoto,S. (2003).Biological characteristics of the junctional epithelium.Journal of electron microscopy,52(6),627-639.
[3] Fujii, N., Kusakari, H., & Maeda, T. (1998). A histological study on tissue responses to titanium implantation in rat maxilla:the process of epithelial regeneration and bone react ion.Journal of periodontology,69(4),485-495.
[4] Atsuta,I.,Yamaza,T., Yoshinari, M., Mino, S., Goto, T., Kido, M.A.,Terada,Y.,& Tanaka,T.(2005). Changes in the distribution of laminin-5during peri-implant epithelium formation after immediate titanium implantation in rats.Biomaterials,26(14), 1751-1760.
[5] Mackenzie,I.C.,& Tonetti, M.S.(1995).Formation of normal gingival epithelial phenotypes around osseo-integrated oral implants in humans.Journal of periodontology,66(11),933-943.
[6] Yajima-Himuro,S.,Oshima,M.,Yamamoto,G.et al.The junct ional epithelium originates from the odontogenic epithelium of an erupted tooth.Sci Rep4,4867(2014).
[7] Tanaka, K.,Tanaka, J.,Aizawa, R.etal.Structure of juncti onal epithelium is maintained by cell populations supplied from multiple stem cells.Sci Rep 11,18860(2021).
[8] Yuan, X.,Chen, J., Grauer, J. A., Xu, Q., Van Brunt, L. A., & Helms, J. A. (2021). The Junctional Epithelium Is Maintained by a Stem Cell Population. Journal of dental research,100(2), 209-216.
[9] Stern I.B.(1981).Current concepts of the dentogingiv al junction: the epithelial and connective tissue attachments to the tooth.Journal of periodontology,52(9),465-476.
[10] Hatakeyama,S.,Yaegashi,T.,Oikawa,Y.,Fujiwara,H.,Mikami, T.,Takeda, Y., & Satoh, M. (2006). Expression pattern of adhesion molecules in junctional epithelium differs from that in other gingival epithelia.Journal of periodontal research,41(4),322-328.
[11] Kinumatsu,T., Hashimoto, S., Muramatsu, T., Sasaki, H., Jung,H.S.,Yamada,S.,& Shimono,M. (2009). Involvement of lamininand integrins in adhesion and migration of junctional epith elium cells.Journal of periodontal research,44(1),13-20.
[12] Uitto,V.J., Salonen, J. I., Firth, J. D., Jousimies-Somer, H.,& Saarialho-Kere,U.(2002).Matrilysin (matrix metalloprote inase-7) expression in human junctional epithelium.Journal of dental research,81(4),241-246.
[13] 李树波,李德懿&葛锡锐.人结合上皮细胞体外培养与冻存方法的改良[J].上海口腔医学,2007(03):263-267.
[14] Oh, C., Kim, H. J., & Kim, H. M. (2022). Transepithelial channels for leukocytes in the junctional epithelium.Journal of periodontalresearch,57(5),1093-1100.
[15] Jiang, Q.,Yu, Y.,Ruan,H.,Luo,Y.,& Guo,X.(2014).Morpholog ical and functional characteristics of human gingival junctio nal epithelium.BMC oral health,14,30.
[16] Mulla,S.A.,Patil,A., Mali, S., Jain, A., Sharma, D., Jaiswal, H.C.,Saoji,H.A.,Jakhar,A.,Talekar,S., & Singh, S. (2023). Exploring the Biological Width in Dentistry: A Comprehensive Narrative Review.Cureus,15(7),e42080.
[17] Zheng,Z., Ao, X., Xie, P., Jiang, F., & Chen, W. (2021). The biological width around implant.Journal of prosthodontic research,65(1),11-18.
[18] Steflik, D. E., McKinney, R. V., Jr, & Koth, D. L. (1988).Epithelial attachment to ceramic dental implants.Annals of the New York Academy of Sciences,523,4-18.
[19] 陈东晖,黄海云&丁一.层粘连蛋白-5结构及功能的研究进展[J].国际口腔医学杂志,2007(03),181-184.
[20] Kivelä-Rajamäki, M. J., Teronen, O. P., Maisi, P., Husa,V., Tervahartiala, T. I., Pirilä, E. M., Salo, T. A., Mellanen, L., & Sorsa,T.A.(2003).Laminin-5 gamma2-chain and collagenase-2 (MMP-8) in human peri-implant sulcular fluid.Clinical oral implants research,14(2),158-165.
[21] Tamura,R. N., Oda, D., Quaranta, V., Plopper, G., Lambert, R., Glaser, S., & Jones, J. C.(1997). Coating of titanium alloywith soluble laminin-5 promotes cell attachment and hemide smosome assembly in gingival epithelial cells: potential appl ication to dental implants.Journal of periodontal research, 32(3),287-294.
[22] Aellos,F.,Grauer,J.A., Harder, K. G., Dworan, J. S., Fabbri, G., Cuevas, P. L., Yuan, X., Liu, B., Brunski, J. B., & Helms, J. A. (2024). Dynamic analyses of a soft tissue-implant interface: Biological responses to immediate versus delayed dental implants.Journal of clinical periodontology,51(7), 806-817.
[23] Baker, S. E., Hopkinson, S. B., Fitchmun, M., Andreason, G. L., Frasier, F., Plopper, G., Quaranta, V., & Jones, J. C. (1996). Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly.Journal of cell science,109(Pt10),2509-2520.
[24] Atsuta,I.,Yamaza,T.,Yoshinari,M.,Goto,T.,Kido,M.A.,Kagiya,T., Mino, S., Shimono, M., & Tanaka, T. (2005). Ultrastructural localization of laminin-5(gamma2 chain)in the rat peri-impla nt oral mucosa around a titanium-dental implant by immuno -electron microscopy.Biomaterials,26(32),6280-6287.
[25] Hormia,M.,Sahlberg,C.,Thesleff, I., & Airenne, T. (1998). The epithelium-tooth interface--a basal lamina rich in laminin -5 and lacking other known laminin isoforms.Journal of dental research,77(7),1479-1485.
[26] Hohenester E.(2019).Structural biology of laminins. Essays in biochemistry,63(3),285-295.
[27] Mizushima, H., Koshikawa, N., Moriyama, K., Takamura, H., Nagashima,Y.,Hirahara,F.,& Miyazaki,K.(1998). Wide distributionof laminin-5 gamma 2 chain in basement membranes of various human tissues.Hormone research,50 Suppl2,7-14.
[28] Oksanen,J.,& Hormia, M. (2002). An organotypic in vitro model that mimics the dento-epithelial junction.Journal of periodontology,73(1),86-93.
[29] Driemel, O.,Dahse,R.,Hakim, S. G., Tsioutsias, T., Pistner,H., Reichert,T.E.,& Kosmehl,H.(2007).Laminin-5 immunocytoche mistry: a new tool for identifying dysplastic cells in oral brush biopsies.Cytopathology : official journal of the British Society for Clinical Cytology,18(6),348-355.
[30] Goldfinger,L.E.,Stack,M.S.,&Jones,J.C.(1998).Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator.The Journal of cell biology,141(1),255-265.
[31] Hormia,M.,Owaribe,K.,& Virtanen,I.(2001).The dentoepithelial junction: cell adhesion by type I hemidesmosomes in the absence of a true basal lamina. Journal of periodo ntology,72(6),788-797.
[32] Haas, M., Berndt, A., Hyckel, P., Stiller, K. J., & Kosmehl, H.(2000).Laminin-5 bei Erkrankungen der Mundhöhle [Laminin -5 in diseases of the oral cavity].Mund-,Kiefer-und Gesichts chirurgie:MKG,4(1),25-29.
[33] Dabelsteen,E.,Grøn,B.,Mandel,U., & Mackenzie, I. (1998). Altered expression of epithelial cell surface glycoconjugates and intermediate filaments at the margins of mucosal wounds. The Journal of investigative dermatology,111(4),592-597.
[34] Kainulainen,T.,Hakkinen,L.,Hamidi,S.,Larjava,K.,Kallioinen, M., Peltonen, J., Salo, T., Larjava, H., & Oikarinen, A. (1998). Laminin-5 expression is independent of the injury and the microenvironment during reepithelialization of wounds.Thejournal of histochemistry and cytochemistry: official journal of the Histochemistry Society,46(3),353-360.
[35] Vallée,A.,Faga, M. G., Mussano, F., Catalano, F., Tolosano, E., Carossa,S.,Altruda, F., & Martra, G. (2014). Alumina-zirconia composites functionalized with laminin-1 and laminin-5 for dentistry:effect of protein adsorption on cellular response. Colloids and surfaces.B, Biointerfaces,114,284-293.
[36] Zhang, K., & Kramer, R. H. (1996). Laminin 5 deposition promotes keratinocyte motility.Experimental cell research, 227(2),309-322.
[37] Gürses,N.,Thorup,A.K.,Reibel,J.,Carter,W.G.,&Holmstrup, P.(1999).Expression of VLA-integrins and their related basem ent membrane ligands in gingiva from patients of various periodontitis categories.Journal of clinical periodontology, 26(4),217-224.
[38] Goldfinger,L.E.,Stack,M.S.,& Jones,J.C.(1998).Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator.The Journal of cell biology,141(1),255-265.
[39] Kivelä-Rajamäki, M. J., Teronen, O. P., Maisi, P., Husa, V.,Tervahartiala,T.I.,Pirilä,E.M., Salo, T. A., Mellanen, L., & Sorsa, T.A.(2003).Laminin-5 gamma2-chain and collagenase-2 (MMP-8) in human peri-implant sulcular fluid. Clinical oral implants research,14(2),158-165.
[40] Shimono, M., Ishikawa, T., Enokiya, Y., Muramatsu, T., Matsuzaka, K., Inoue, T., Abiko, Y., Yamaza, T., Kido, M. A., Tanaka, T., & Hashimoto, S.(2003). Biological characteristics of the junctional epithelium.Journal of electron microscopy,52(6),627-639.
[41] Nguyen,B.P.,Gil,S. G., & Carter, W. G. (2000). Deposition of laminin 5 by keratinocytes regulates integrin adhesion and signaling.The Journal of biological chemistry,275(41), 31896 -31907.
[42] Engvall,E.,&Wewer,U.M.(1996).Domains of laminin.Journ al of cellular biochemistry,61(4),493-501.
[43] Oksonen,J.,Sorokin, L. M., Virtanen, & Hormia, M. (2001). The junctional epithelium around murine teeth differs from gingival epithelium in its basement membrane composition. Journal of dental research,80(12),2093-2097.
[44] Masaoka,T., Hashimoto, S., Kinumatsu, T., Muramatsu, T., Jung, H. S., Yamada, S., & Shimono, M. (2009). Immunolocalization of laminin and integrin in regenerating junctional epitheli um of mice after gingivectomy.Journal of periodontal resear ch,44(4),489-495.
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