雄激素性脱发的治疗进展研究

Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i4.8503

三芬娟, 郭砚

青海大学

Abstract

脱发是临床上常见的一种毛发疾病,雄激素性脱发(Androgenic alopecia,AGA)是其中最常见的类型之一。其特征是明显的渐进性脱发。AGA主要发生在男性身上,由遗传易感性和毛囊对雄激素的过度敏感性引起,导致头皮终毛逐渐转变为毳毛。本文旨在通过对雄激素性脱发治疗方法相关文献的梳理和评价,进一步阐明雄激素性脱发的发病机制及不同治疗方案的临床有效性及安全性。为临床研究人员提供关于治疗雄激素性脱发全面、深入的了解。

Keywords

雄激素性脱发;发病机制;治疗方法

References

[1] 李盛,黄茜,陈敏.雄激素性脱发的发病机制与激光治疗[J].激光生物学报,2016,25(02):107-111.
[2] Stefanie H,K A K ,Nadine F , et al.Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology.[J].The Journal of investigative dermatology,2013,133(6):1489-96.
[3] 孙建林,吕新翔.雄激素性脱发的发病机制与治疗进展[J].内蒙古医科大学学报,2020,42(01):106-108+112.
[4] 杨堃,付聪,凌佳琦,等.A型肉毒毒素治疗雄激素性脱发的机制及研究进展[J].中国美容整形外科杂志,2022,33(01):23-25.
[5] Maher SA,Ismail NA,Toraih EA,etal.Hair Follicle-Relat ed MicroRNA-34a Serum Expression and rs2666433A/G Variant in Patients with Alopecia:A Cross-Sectional Analysis. Biomol ecules.2022;12(5):
[6] 刘琴月.雄激素性脱发患病影响因素分析[D].华北理工大学,2022.
[7] Kaliyadan F, Nambiar A,Vijayaraghavan S. Androgenetic alopecia:an update. Indian J DdermatolVenereolLeprol. 2013; 79(5):613.doi:10.4103/0378-6323.116730.
[8] MessengerAG,RundegrenJ.Minoxidil:mechanism so facti on on hair growth.Br JDermatol.2004;150(2):186-94.
[9] 吴巍,赵宏伟.雄激素性脱发药物治疗及新药研究进展[J].组织工程与重建外科,2021,17(05):445-449.
[10] Ruiming H ,Feng X ,Youyu S , et al.Combined treatment with oral finasteride and topical minoxidil in male androge netic alopecia: a randomized and comparative study in Chinese patients.[J].Dermatologic therapy,2015,28(5):303-8.
[11] A T,M B P,M S. Evaluation of sexual function in subj ects taking finasteride for the treatment of androgenetic alopecia.[J]. Journal of the European Academy of Dermatology and Venereology:JEADV,2001,15(5).
[12] 吴大兴,吴丽峰.激光疗法在雄激素性脱发中的应用[J].中国麻风皮肤病杂志,2020,36(04):249-252.
[13] T.Arif,K.Dorjay,M.Adil,M.SamiDutasteride in androgen etic alopecia:an update Curr ClinPharmacol,12(2017),pp.3135,10.2174/1574884712666170310111125.
[14] Ntshingila S,Oputu O,Arowolo A T,etal.Androgenetic alopecia:An update[J].JAAD international,2023,13:150-158.
[15] S H ,R D N ,F F B , et al.No genetic support for a contribution of prostaglandins to the aetiology of androge netic alopecia.[J].The British journal of dermatology,2013,169(1):222-4.
[16] 韦菊梅.盐酸左西替利嗪对人毛乳头细胞生长影响的初步研究[D].广西医科大学,2019.
[17] A R ,D C ,C M F , et al.A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia.[J].The Journal of dermatological treatment,2018,29 (2):149-151.
[18] Delaram M H ,Aniseh S ,Somayeh N , et al.Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study.[J].Journal of pharmacy & pharmaceutical sciences:a publication of the Canadian Society for Pharmace utical Sciences, Societe canadienne des sciences pharmaceuti ques,2021,24191-199.
[19] Stevens J,Khetarpal S.Platelet-rich plasma for andro genetic alopecia: A review of the literature and proposed treatment protocol[J].International Journal of Women's Derma tology,2019,5(1):46-51.
[20] Castro M F ,Grassi A S ,Rodrigo G , et al.Complications with the use of botulinum toxin type a in facial rejuvenation: report of 8 cases.[J].Aesthetic plastic surgery,2004,28(6):441-4.
[21] J B F,Marvin S. Treatment of male pattern baldness with botulinum toxin: a pilot study.[J]. Plastic and reconstr uctive surgery,2010,126(5).
[22] 章晾.肉毒毒素注射联合中胚层疗法治疗雄激素性脱发[J].中国医疗美容,2018,8(06):12-14.
[23] 崔晶,金珊,南美兰,等.A型肉毒素下调UVB诱导的HaCaT细胞炎症因子的表达[J].中国皮肤性病学杂志,2019,33(10):1121-1124.
[24] Hussein RS, Dayel SB, Abahussein O. Botulinum Toxin A for Hair Loss Treatment: A Systematic Review of Efficacy, Safety, and Future Directions. JPRAS open.2023 Sep 21.
[25] 李翔英,廉翠红,陆原.低能量激光联合非那雄胺治疗雄激素性脱发的临床研究[J].中国医疗美容,2018,8(02):36-38.
[26] Huang W ,Foster A J ,Rogachefsky S A .Pharmacology of botulinum toxin[J].Journal of the American Academy of Derma tology,2000,43(2):249-259.

Copyright © 2024 三芬娟, 郭砚

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License