氯离子通道TMEM16A在肿瘤发生发展中的研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i4.8498
Abstract
TMEM16A是一种广泛存在于多种组织细胞的跨膜氯离子通道蛋白,具有重要的生理作用。TMEM16A在多种癌细胞中过表达,与癌症的发生、发展密切相关。探索TMEM16A在人类组织细胞中的分布及其抗肿瘤的作用,对于肿瘤的诊断和治疗来说非常重要。本文主要总结了TMEM16A在肿瘤发生发展中的作用,并且讨论了将TMEM16A作为生物靶点在肿瘤诊断和治疗中发挥的作用。
Keywords
氯离子通道；TMEM16A；肿瘤；发生发展
Funding
吉林省教育厅科学技术研究项目(项目编号：JJKH20210484KJ)。
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[4] 王悦,徐恩君,杨玉萍,等.PSMD14在胰腺癌中的表达分析及对胰腺癌细胞增殖的影响[J].国际检验医学杂志,2023,44(4):385-390+395
[5] 柯永莉,李黎,寇晓梅,等.乳腺癌组织miR-381和跨膜蛋白16A表达与临床病理特征及预后的关系[J].中华实用诊断与治疗杂志,2022,36(7):714-718.
[6] 谭佳杰,张洪,范月莹,等.TMEM16A在肿瘤中的研究进展[J].华中科技大学学报(医学版),2022,51(6):879-883.
[7] MazzoneA,Gibbons SJ,Bernard CE,et al. Identification and characterization of a novel promoter for the human ANO1 gene regulated by the transcription factor signal transducer and activator of transcription 6(STAT6)[J].Faseb J,2015,29(1):152-163.
[8] Qin Y,Jiang Y,Sheikh AS,etal.Interleukin-13 stimulates MUC5AC expression via a STAT6-TMEM16A-ERK1/2 pathway in human airway epithelial cells[J].Int Immunopharmacol, 2016, 40:106-114.
[9] Cha JY,Wee J,Jung J,et al. Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia[J]. Proc Natl Acad Sci USA,2015,112(31):9722-9727.
[10] Dixit R,Kemp C,Kulich S,etal.TMEM16A/ANO1 is differe ntially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation [J].Sci Rep,2015,5:16657.
[11] Cao Q,Liu F,Ji K,et al. MicroRNA-381 inhibits the metastasis of gastric cancer by targeting TMEM16A expression [J].J Exp Clin Cancer Res,2017,36(1):29.
[12] 郑晓恬,高凤彤,石权,等.ANO1介导肿瘤恶性生物学行为的机制探讨[J].现代肿瘤医学,2024,32(3):561-565.
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