妊娠期无症状高尿酸血症的相关研究

Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i4.8476

张惠然1, 何君兰1, 李美华1, 郭铁标2

1. 承德医学院
2. 沧州市人民医院

Abstract

尿酸(UA)是嘌呤代谢的最终代谢产物。早期,尿酸被认为是一种具有一定抗氧化能力的代谢物。随着研究的进展,人们还探索了尿酸的其他特性,并发现它与许多疾病有关。尿酸与肾脏疾病和心血管疾病之间的联系已经得到了很好的证实;然而,关于尿酸与女性生殖系统之间的联系的综述仍然很少。研究显示,血尿酸水平(SUA)与女性妊娠结局具有相关性。妊娠期高尿酸血症(HUA)可引起一系列妊娠并发症,导致不良妊娠结局。而关于无症状HUA是否需要积极降尿酸治疗更是存在较大争议。综述尿酸对妊娠期女性的影响,以期为临床上的预防及诊疗提供新的策略。

Keywords

尿酸;高尿酸血症;妊娠期

References

[1] J.Lu,N.Dalbeth,H.Yin,C.Li,T.R.Merriman,W.H.Wei,Mouse mo dels for human hyperuricaemia: a critical review, Nat. Rev. Rheumatol.15(2019):413-426.
[2] B.´Alvarez-Lario,J.Macarr´on-Vicente, Uric acid and evolution, Rheumatology(Oxford)49(2010)2010-2015.
[3] Z.Zhou,Z.Li, C. Wang, X. Li, X. Cheng, C. Li, Y. Shi, Commonvariants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese, Here ditas156(2019)4.
[4] K.Zhang,C.Li, ABCG2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol res ponse in primary gout patients of a Chinese Han male popu lation,Hereditas156(2019)26.
[5] G. Cab˘au, T.O. Crișan, V. Klück, R.A. Popp, L.A.B. Joosten, Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia,Immunol.Rev.294 (2020)92-105.
[6] M.Jena,A.Tripathy,A.Mishra,R.Maiti,Effect of canakinu mab on clinical and biochemical parameters in acute gouty arthritis:A meta-analysis,Inflammopharmacology29(2021)35- 47.
[7] C.A. Janssen, M.A. Oude Voshaar, H.E. Vonkeman, T.L.T.A. Jansen, M. Janssen,M.R. Kok, B. Radovits, C. van Durme, H. Baan, M.A. van de Laar, Anakinra for the treatment of acute gout flares:a randomized, double-blind, placebo-controlled,active -comparator, non-inferiority trial, Rheumatology (Oxford, England) 58(2019)1344-1352.
[8] L.A.B. Joosten, T.O. Cris¸an, P. Bjornstad, R.J. Johnson, Asymptomatic hyperuricaemia: a silent activator of the innate immune system, Nat. Rev.Rheumatol.16(2020)75-86.
[9] Y. Yu, N. Zhang, X. Dong, N. Fan, L. Wang, Y. Xu, H. Chen, W. Duan, Uricase-deficient rat is generated with CRISPR/Cas9 technique,PeerJ 8(2020) e8971.
[10] Kuwabara M, Niwa K, Hisatome I, et al. Asymptomatic hyperuricemia without comorbidities predicts cardiometabol ic diseases: Five-Year Japanese Cohort Study[J].Hypertension,2017,69(6):1036-1044.
[11] Khaliq OP, Konoshita T, Moodley J, Naicker T. The Role of Uric Acid in Preeclampsia: Is Uric Acid a Causative Factor or a Sign of Preeclampsia? Curr Hypertens Rep. 2018,10;20 (9):80.
[12] Bainbridge SA, Roberts JM. Uric acid as a pathogenic factor in preeclampsia. Placenta. 2008,29 Suppl A(Suppl A):S67-72.
[13] Roberts JM, Bodnar LM, Lain KY, et al. Uric acid is as important as proteinuria in identifying fetal risk in women with gestational hypertension[J].Hypertension. 2005,46(6):1263-1269.
[14] C R, Samal S, Ghose S. Association of Elevated first Trimester Serum Uric Acid Levels with Development of GDM. J Clin Diagn Res.2014,8(12):OC01-5.
[15] Leng J, Wang L, Wang J, Li W, Liu H, Zhang S, Li L, Tian H, Xun P, Yang X, Yu Z, Hu G. Uric acid and diabetes risk amongChinese women with a history of gestational diabetes mellitus. Diabetes Res Clin Pract.2017,134:72-79.
[16] Molęda P, Fronczyk A, Safranow K, Majkowska L. Is Uric Acid a Missing Link between Previous Gestational Diabetes Mellitus and the Development of Type 2 Diabetes at a Later Time of Life? PLoS One. 2016,11(5):e0154921.
[17] Pleskacova A, Bartakova V, Chalasova K, Pacal L, Kankova K, Tomandl J. Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes Mellitus-The Effect on Adverse Pregnancy Outcomes.Int J Mol Sci. 2018,21;19(11):3696.
[18] C R, Samal S, Ghose S. Association of Elevated first Trimester Serum Uric Acid Levels with Development of GDM[J].J Clin Diagn Res.2014,8(12):OC01-OC05.
[19] Cheung KL,Lafayette RA.Renal physiology of pregnancy [J].Adv Chronic Kidney Dis,2013,20(3):209-214.
[20] Kang DH,Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression:implication on cell proliferat ion and nitric oxide production of human vascular cells. J Am Soc Nephrol. 2005,16(12):3553-62.
[21] Kanellis J, Watanabe S, Li JH, Kang DH, Li P, Nakagawa T, Wamsley A, Sheikh-Hamad D, Lan HY, Feng L, Johnson RJ. Uric acid stimulates monocyte chemoattractant protein-1 product ion in vascular smooth muscle cells via mitogen-activated pro tein kinase and cyclooxygenase-2.Hypertension. 2003,41(6): 1287-93.
[22] Wei L,Ji H,Song W,etal.Hypouricemic, hepatoprotective and nephroprotective roles of oligopeptides derived from Auxis thazard protein in hyperuricemic mice, Food Funct. 12 (2021)11838-11848.
[23] H.K.Choi, K. Atkinson, E.W. Karlson, W. Willett, G. Curhan,Purine-rich foods,dairy and protein intake, and the risk of gout in men,N.Engl.J.Med.350(2004)1093-1103.
[24] L.G.Sanchez-Lozada, B. Rodriguez-Iturbe, E.E. Kelley, T. Nakagawa,M.Madero,D.I.Feig,C.Borghi,F.Piani,G. CaraFuentes,P.Bjornstad,M.A.Lanaspa,R.J.Johnson,Uric acid and hypertension:an update with recommendations, Am. J.Hypertens. 33 (2020) 583-594.
[25] N.Dalbeth,H.K.Choi,L.A.B.Joosten,P.P. Khanna, H. Matsuo, F.Perez-Ruiz,L.K.Stamp,Gout,Nat.Rev.Disease Primers 5(2019)69.

Copyright © 2024 张惠然, 何君兰, 李美华, 郭铁标

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License