QSM在神经退行性疾病中的应用研究
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i3.7536
Abstract
神经退行性疾病是一类以神经元丢失、特定区域的细胞死亡和萎缩及脑铁沉积为主要特征的异质性复杂疾病,给社会带来了沉重的医疗负担。近年来,随着铁稳态失调学说的提出,QSM这一非侵入性的磁敏感定量成像技术被广泛应用于神经退行性疾病的研究,凭借其定量、无创、分辨率高等独特优势,QSM技术有望成为探索各种神经退行性疾病的发病机制、早期诊断标准及治疗策略的可靠工具。因此,本文就QSM技术在帕金森病、阿尔茨海默病、亨廷顿病、肌萎缩侧索硬化症及多发性硬化等神经退行性疾病中的应用现状进行综述。
Keywords
定量磁化率成像；铁沉积；神经退行性疾病
Full Text
PDF - Viewed/Downloaded: 0 TimesReferences
[1] Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study[J]. NeuroImage,2012,62(3):1593-1599.
[2] Nathoo N,Gee M,Nelles K,etal.Quantitative Susceptibili ty Mapping Changes Relate to Gait Issues in Parkinson’s Dise ase[J]. Canadian Journal of Neurological Sciences, 2023, 50(6):853-860.
[3] Sacchi L, Contarino V E, Siggillino S, et al. Banks of the Superior Temporal Sulcus in Alzheimer’s Disease: A Pilot Quantitative Susceptibility Mapping Study[J]. Journal of Alz heimer’s Disease,2023,93(3):1125-1134.
[4] Van Bergen J M G,Hua J,Unschuld P G, et al. Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Prema nifest Huntington Disease[J].American Journal of Neuroradio logy,2016,37(5):789-796.
[5] Bhattarai A, Chen Z, Ward P G D, et al. Serial assessment of iron in the motor cortex in limb-onset amyotrophic lateral sclerosis using quantitative susceptibility mapping[J]. Quan titative Imaging in Medicine and Surgery,2020,10(7):1465-1476.
[6] Dean K E, Shen B, Askin G, et al. A specific biomarker for amyotrophic lateral sclerosis: Quantitative susceptibility mapping[J].Clinical Imaging, 2021,75:125-130.
[7] Lo Russo F, Contarino V E, Conte G, et al. Amyotrophic lateral sclerosis with upper motor neuron predominance: diag nostic accuracy of qualitative and quantitative susceptibili ty metrics in the precentral gyrus[J].European Radiology, 2023,33(11):7677-7685.
[8] Voon C C, Wiltgen T, Wiestler B, et al. Quantitative susc eptibility mapping in multiple sclerosis: A systematic review and meta-analysis[J]. NeuroImage: Clinical,2024,42:103598.
[9] Zinger N, Ponath G, Sweeney E, et al. Dimethyl Fumarate Reduces Inflammation in Chronic Active Multiple Sclerosis Lesions[J]. Neurology Neuroimmunology & Neuroinflammation, 2022,9(2):e1138.
[10] 殷菲悦,李咏梅,丁爽,等.复发缓解型多发性硬化患者黑质亚区的定量磁化率成像研究[J].中华放射学杂志,2023,57(6):632-639.
[2] Nathoo N,Gee M,Nelles K,etal.Quantitative Susceptibili ty Mapping Changes Relate to Gait Issues in Parkinson’s Dise ase[J]. Canadian Journal of Neurological Sciences, 2023, 50(6):853-860.
[3] Sacchi L, Contarino V E, Siggillino S, et al. Banks of the Superior Temporal Sulcus in Alzheimer’s Disease: A Pilot Quantitative Susceptibility Mapping Study[J]. Journal of Alz heimer’s Disease,2023,93(3):1125-1134.
[4] Van Bergen J M G,Hua J,Unschuld P G, et al. Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Prema nifest Huntington Disease[J].American Journal of Neuroradio logy,2016,37(5):789-796.
[5] Bhattarai A, Chen Z, Ward P G D, et al. Serial assessment of iron in the motor cortex in limb-onset amyotrophic lateral sclerosis using quantitative susceptibility mapping[J]. Quan titative Imaging in Medicine and Surgery,2020,10(7):1465-1476.
[6] Dean K E, Shen B, Askin G, et al. A specific biomarker for amyotrophic lateral sclerosis: Quantitative susceptibility mapping[J].Clinical Imaging, 2021,75:125-130.
[7] Lo Russo F, Contarino V E, Conte G, et al. Amyotrophic lateral sclerosis with upper motor neuron predominance: diag nostic accuracy of qualitative and quantitative susceptibili ty metrics in the precentral gyrus[J].European Radiology, 2023,33(11):7677-7685.
[8] Voon C C, Wiltgen T, Wiestler B, et al. Quantitative susc eptibility mapping in multiple sclerosis: A systematic review and meta-analysis[J]. NeuroImage: Clinical,2024,42:103598.
[9] Zinger N, Ponath G, Sweeney E, et al. Dimethyl Fumarate Reduces Inflammation in Chronic Active Multiple Sclerosis Lesions[J]. Neurology Neuroimmunology & Neuroinflammation, 2022,9(2):e1138.
[10] 殷菲悦,李咏梅,丁爽,等.复发缓解型多发性硬化患者黑质亚区的定量磁化率成像研究[J].中华放射学杂志,2023,57(6):632-639.
Copyright © 2024 王佳乐, 王胜林
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License