CHI3L1在原发性肝癌中的表达及与预后的关系
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v4i3.5211
Abstract
目的：探究几丁质酶-3样蛋白1 CHI3L1在原发性肝癌组织中的表达及其与预后的关系。方法：收集2003年4月至2009年9月在海军军医大学附属东方肝胆外科医院行手术切除的77例原发性肝细胞癌患者癌组织及相应癌旁组织,利用免疫组织化学染色法检测CHI3L1在两种组织中的表达量,并分析CHI3L1的表达和患者临床特征及预后的关系。结果：CHI3L1在原发性肝癌中的阳性表达率低于癌旁组织,差异具有统计学意义(P<0.05)；与低表达组相比,CHI3L1高表达组的累计复发率更低(p<0.05),并且总体生存时间更长(p<0.05)。此外,CHI3L1的表达与患者性别、年龄、门脉癌栓及抑癌因子P53均无统计学差异(>0.05)。结论：CHI3L1在原发性肝癌组织中的阳性表达率较低,并且高表达的患者预后较好,提示我们可以将CHICL1作为原发性肝癌的一个预后参考指标,对患者预后判断具有一定的参考价值。
Keywords
原发性肝癌；CHI3L1；预后
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