JAK/STAT信号通路在急性胰腺炎疾病发生中的作用
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v4i3.5206
Abstract
JAK/STAT信号通路广泛参与机体免疫调节、增殖、分化、迁移、凋亡等生理过程,是大多数细胞、各类因子重要的信号转导通路。JAK/STAT信号通路和炎症相关疾病关系密切,在急性胰腺炎疾病发生发展及器官损伤中起重要作用。
Keywords
JAK/STAT；急性胰腺炎；器官损伤
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[6] .Villarinoa V, Kanno Y, Ferdinand J R, et al. Mechanisms of JAK/STAT signaling in immunity and disease[J].J Immunol,
[7] .Koppikar, P. Alaski N,Domingo,H, et al. Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature,2012,489,155-159.
[8] Springuel L, Trouslog H, Deyuevki J, et al. Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors. Blood, 2014,124,3924-3931.
[9] . Spangler, J.B., Moraga, I., Mendoza, J.L. & Garcia, K.C. Insights into cytokine-receptor interactions from cytokine engineering. Annu. Rev. Immunol. 2015, 33, 139–167.
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