代谢综合征及其组分与胃癌相关性的研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v4i1.4792
Abstract
我国是胃癌的高发国家。胃癌的发生与多种因素相关,尽管医疗水平较前提高,但胃癌的死亡率仍居高不下。因此推动胃癌的病因学研究并进行早期预防,可以实现降低胃癌的发病率。随着社会的发展,代谢紊乱引起的健康问题日益突出,研究表明多种癌症的发生与代谢性因素相关。代谢综合征是一组以肥胖、高血糖、血脂异常、以及高血压等聚集发病、严重影响机体健康的临床症候群,是一种代谢紊乱的病理状态。有研究表明代谢综合征增加了胃癌的发病风险,本文就代谢综合征及其组分与胃癌的相关性作一综述。
Keywords
胃癌；代谢综合征；肥胖；糖代谢异常；胰岛素抵抗；血脂异常；高血压
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[3] Yoo H, Kim H, Lee JH, et al. Study on the Relevance of Metabolic Syndrom e and Incidence of Gastric Cancer in Korea[J].Int J Environ Res Public Heal th, 2019,16(7):1101.
[4] Li,F;Du,H;Li,S;et al.The Associat ion Between Metabolic Syndrome and Gastric Cancer in Chinese.[J].Front Onc ol.2018,(8):326.
[5] Mariani, M; Sassano, M; Boccia, S; Metabolic syndrome and gastric cancer risk:a systematic review and meta-ana lysis.[J].Eur J Cancer Prev.2021,30(3):239-250.
[6] Li,Z;Han, H; Chang, Y; Association between metabolic syndrome and the incidence of gastric cancer: a metaanalysis of cohortstudies.[J].Diabetol Metab Syndr.2019,(11):83.
[7] Yang,P;Zhou,Y;Chen,B;etal.Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies.[J].Eur J Cancer.2009,45(16):2867-73.
[8] Li HJ,Fu JK,Che XM,et al. Obesity accelerates murine gastric cancer gro wth by modulating the Sirt1/YAP path way.Oncol Lett,2017,14(4): 4151-4157.
[9] Fernandes JV,Cobucci RN, JatobáCAN, et al. The role of the mediators of inflammation in cancer development. Pathol Oncol Res, 2015, 21(3): 527-534.
[10] LIN Y,HE Z, YE J, et al. Progress in Understanding the IL-6/STAT3 Path way in Colorectal Cancer[J].Onco Targ ets Ther,2020,13:13023.
[11] JU X, ZHANG H, ZHOU Z, CHEN M, et al.Tumor-associated macrophages induce PD -L1 expression in gastric ca ncer cells through IL-6 and TNF-ɑ si gnaling[J].Exp Cell Res,2020,396(2):112315.
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[13] MUPPALA S,KONDURU SKP,MERCH ANT N, et al. Adiponectin: Its role in obesity -associated colon and prostate cancers[J].Crit Rev Oncol Hematol,2017, 116:125-133.
[14] XIE L, WANG Y, WANG S, et al. Adiponectin induces growth inhibition and apoptosis in cervical cancer HeLa cells[J]. Biologia,2011,66(4):12-720.
[15] Mauro L, Naimo GD, Gelsomino L, et al. Uncoupling effects of estrogen receptor α on LKB1/AMPK interaction upon adiponectin exposure in breast cancer. FASEB J,2018,32(8): 4343-4355.
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[17] Vansaun MN. 2013. Molecular pathways: adiponectin and leptin sig naling in cancer. Clin. Cancer Res.19:1926-32.
[18] CAO J,YEE D.Disrupting Insulin and IGF Receptor Function in Cancer[J]. Int J Mol Sci, 2021,22(2):555.
[19] Thompson MA,Cox AJ, Whitehead RH,Jonas HA(1990)Auto-crine regulation of humanTumor cell proliferation by insulin-likegrowth factor II: an in vitro model. Endocrinology 126:3033-3042.
[20] Christopoulos PF, Msaouel P, Koutsilieris M.The role of the insulin -like growth factor-1system in breast cancer.Mol Cancer.2015;14:43.[PubMed:25743390].
[21] 苑小星.脂质代谢异常与恶性肿瘤相关性研究进展[J].中国基层医药,2020,27(18):2300-2304.
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[23] Kim EH, Lee H, Chung H, Park JC, Shin SK,Lee SK,et al.Impactof metabolic syndrome on oncologic outcome after radical gastrectomyfor gastric cancer. Clin Res Hepatol Gastroenterol. (2014) 38:372-8.
[24] Sun L, Zhou P,Hua Q, et al. Ef fects of blood glucose, blood lipids and blood pressure control on recovery of patients with gastric cancer complicat ed with metabolic syndrome after radical gastrectomy[J]. Exp Ther Med, 2018,15(6):4785-4790.
[25] Dovell F,Boffetta P. Serum ur ic acid and cancer mortality and incide nce：a systematic review and meta-anal ysis[J].Eur J Cancer Prev,2018,27(4): 399-405.
[26] 梁晓峰,李利娟,刘俊田.代谢综合征与胃癌发病风险及临床病理特征相关性的研究[J].中国肿瘤临床,2019,46(19):986-993.
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