阿芬太尼的药理学和临床应用
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v3i1.3953
Abstract
阿片类药物在临床镇痛中发挥着重要作用。阿芬太尼是的新型的μ阿片受体激动剂,阿芬太尼起效迅速,药物作用可预见性强,剂量容易控制,停药后病人苏醒快。阿芬太尼在国外应用广泛,国产阿芬太尼最近上市,关于阿芬太尼的应用报道还较少。本文对阿芬太尼的药理学进行分析,并讨论其在临床应用的情况,为其在国内临床研究和应用中提供可靠依据。
Keywords
阿芬太尼;药理学;临床应用
Full Text
PDF - Viewed/Downloaded: 0 TimesReferences
[1] Larijani G E,Goldberg M E. Alf entanil hydrochloride: a new short-act ing narcotic analgesic for surgical pro cedures.[J].Clinical pharmacy,1987,6(4).
[2] 尹文记,刘立京,许光炘,等.盐酸阿芬太尼在手术病人中的药代动力学研究[J].中国药物依赖性通报,1994,(02):103-108.
[3] Frederic Camu,Elisabeth Gepts, Michel Rucquoi,Jos Heykants. Pharmaco kinetics of Alfentanil in Man[J]. Anes thesia & Analgesia,1982,61(8).
[4] Gerald V. Goresky,Gideon Koren, M. A. Sabourin,John P. Sale,Leo Strunin. The Pharmacokinetics of Alfentanil in Children[J].Anesthesiology,1987,67(5).
[5] 杨坤渹.阿芬太尼、芬太尼、瑞芬太尼对中老年脑损伤患者脑血流动力学的影响[J].中国老年学杂志,2012,32 (24):5430-5431.
[6] Kovac Anthony L.,Bennets Paul S.,Ohara Susumu,LaGreca Brian A.,Khan Jemshed A.,Calkins John W.. Effect of Esmolol on hemodynamics and intraocu lar pressure response to succinylchol ine and intubation following low-dose alfentanil premedication[J]. Elsevier, 1992,4(4).
[7] James C. Scott,Katherine V. Pon ganis,Donald R. Stanski. EEG Quantitati on of Narcotic Effect: The Comparative Pharmacodynamics of Fentanyl and Alfe ntanil[J]. Anesthesiology,1985,62(3).
[8] Peter S.A Glass,Tong J Gan,Scott Howell,Brian Ginsberg. Drug Interactions: Volatile Anesthetics and Opioids[J]. Journal of Clinical Anesthesia,1997,9(6).
[9] A I McEwan,C Smith,O Dyar,D Goo dman,L R Smith,P S A Glass. Isoflurane Minimum Alveolar Concentration Reduc tion by Fentanyl[J]. Anesthesiology,1993,78(5).
[10] Cheryl L. Westmoreland,Peter S. Sebel,Adam Gropper. Fentanyl or Alfe ntanil Decreases the Minimum Alveolar Anesthetic Concentration of Isofluran e in Surgical Patients[J]. Anesthesia & Analgesia,1994,78(1).
[11] D.J. Pavlin,B. Coda,D. D. Shen,J. Tschanz,Q.Nguyen,R.Schaffer,G.Donaldson,R. C. Jacobson,C. R. Chapman. Effects of Combining Propofol and Alfentanil on Ventilation, Analgesia,Sedation, and Emesis in Human Volunteers[J]. Anesthe siology,1996,84(1).
[12] Jaap Vuyk,Frank H. M. Engbers, Anton G. L. Burm,Arie A. Vletter,Gerard E.R.Griever,Erik Olofsen,James G. Bovill. Pharmacodynamic Interaction between Propofol and Alfentanil When Given for Induction of Anesthesia[J]. Anesthesi ology,1996,84(2).
[13] Donald R.Miller,Raymond J.Mar tineau,Heather OʼBrien,Kathryn A. Hull, Linda Oliveras,Thomas Hindmarsh,Donald Greenway. Effects of Alfentanil on the Hemodynamic and Catecholamine Respo nse to Tracheal Intubation[J]. Anesthe sia & Analgesia,1993,76(5).
[14] Jabbour-Khoury Samar I,Dabb ous Aliya S,Rizk Laudia B,Abou Jalad Naji M,Bartelmaos Tonine E,El-Khatib Mohamad F,Baraka Anis S. A combination of alfentanil-lidocaine-propofol prov ides better intubating conditions than fentanyl-lidocaine-propofol in the absence of muscle relaxants.[J]. Canad ian journal of anaesthesia = Journal canadien d'anesthesie,2003,50(2).
[15] Audrey Shafer,Man-Ling Sung, Paul F. White. Pharmacokinetics and Pha rmacodynamics of Alfentanil Infusions during General Anesthesia[J]. Anesthe sia & Analgesia,1986,65(10):
[16] Gordon Peter C.,Morrell David F.,Pamm Julian D.. Total intravenous an esthesia using propofol and alfentanil for coronary artery bypass surgery[J]. W.B. Saunders,1994,8(3):
[17] Van Aken H,Van Hemelrijck J,Merckx L,Möllhoff T,Mulier J,Lübbesm eyer H J. [Total intravenous anesthesia using propofol and alfentanil in comparison with balanced anesthesia in neurosurgery].[J]. Anasthesie, Intensiv therapie, Notfallmedizin,1990,25(1):
[18] Van Hemelrijck Jan,Van Aken Hugo,Merckx Luc,Mulier Jan. Anesthesia for craniotomy: Total intravenous anes thesia with propofol and alfentanil compared to anesthesia with thiopental sodium, isoflurane, fentanyl, and nitro us oxide[J]. Elsevier,1991,3(6):
[19] 高宇晨,王越夫,王春蓉,等.成年人心脏手术快速通道麻醉对术后并发症影响的研究进展[J].国际麻醉学与复苏杂志,2019,4(06):585-589.
[20] Ahonen J,Olkkola K T,Hynynen M,Seppälä T,Ikävalko H,Remmerie B,Salm enperä M. Comparison of alfentanil, fentanyl and sufentanil for total intravenous anaesthesia with propofol in patients undergoing coronary artery bypass surgery.[J]. British journal of anaesthesia,2000,85(4):
[21] Hynynen M,Takkunen O,Salmenp erä M,Haataja H,Heinonen J. Continuous infusion of fentanyl or alfentanil for coronary artery surgery. Plasma opiate concentrations, haemodynamics and pos toperative course.[J]. British journal of anaesthesia,1986,58(11):
[22] D.W.Blake,C.F.Royse,A.G.Royse,A. R.Bjorksten,P.F.Soeding,J.Pang.Alfentanil Infusion as a Component of Intra venous Anaesthesia for Coronary Artery Bypass Surgery with “Fast-track”Recovery[J]. Anaesthesia and Intensive Care,2003,31(2):
[23] Janet D.Pavlin,Rosalin H.Arends, Holly C. Gunn,Gail Van Norman,Meagan E. Koerschgen,Danny D. Shen. Optimal Pro pofol-Alfentanil Combinations for Su pplementing Nitrous Oxide for Outpati ent Surgery[J].Anesthesiology,1999,91(1):
[24] 覃慧君,黄守国.足月分娩应激反应的研究进展[J].海南医学,2014,25(3):387-389.
[25] Hill D A,McCarthy G,Bali I M. Epidural infusion of alfentanil or dia morphine with bupivacaine in labour- -a dose finding study.[J]. Anaesthesia, 1995,50(5):
[26] D.A.Hughes,D. A. Hill. Intrathe cal alfentanil with and without bupiva caine for analgesia in labour[J]. Anaes thesia,2000,55(11):
[2] 尹文记,刘立京,许光炘,等.盐酸阿芬太尼在手术病人中的药代动力学研究[J].中国药物依赖性通报,1994,(02):103-108.
[3] Frederic Camu,Elisabeth Gepts, Michel Rucquoi,Jos Heykants. Pharmaco kinetics of Alfentanil in Man[J]. Anes thesia & Analgesia,1982,61(8).
[4] Gerald V. Goresky,Gideon Koren, M. A. Sabourin,John P. Sale,Leo Strunin. The Pharmacokinetics of Alfentanil in Children[J].Anesthesiology,1987,67(5).
[5] 杨坤渹.阿芬太尼、芬太尼、瑞芬太尼对中老年脑损伤患者脑血流动力学的影响[J].中国老年学杂志,2012,32 (24):5430-5431.
[6] Kovac Anthony L.,Bennets Paul S.,Ohara Susumu,LaGreca Brian A.,Khan Jemshed A.,Calkins John W.. Effect of Esmolol on hemodynamics and intraocu lar pressure response to succinylchol ine and intubation following low-dose alfentanil premedication[J]. Elsevier, 1992,4(4).
[7] James C. Scott,Katherine V. Pon ganis,Donald R. Stanski. EEG Quantitati on of Narcotic Effect: The Comparative Pharmacodynamics of Fentanyl and Alfe ntanil[J]. Anesthesiology,1985,62(3).
[8] Peter S.A Glass,Tong J Gan,Scott Howell,Brian Ginsberg. Drug Interactions: Volatile Anesthetics and Opioids[J]. Journal of Clinical Anesthesia,1997,9(6).
[9] A I McEwan,C Smith,O Dyar,D Goo dman,L R Smith,P S A Glass. Isoflurane Minimum Alveolar Concentration Reduc tion by Fentanyl[J]. Anesthesiology,1993,78(5).
[10] Cheryl L. Westmoreland,Peter S. Sebel,Adam Gropper. Fentanyl or Alfe ntanil Decreases the Minimum Alveolar Anesthetic Concentration of Isofluran e in Surgical Patients[J]. Anesthesia & Analgesia,1994,78(1).
[11] D.J. Pavlin,B. Coda,D. D. Shen,J. Tschanz,Q.Nguyen,R.Schaffer,G.Donaldson,R. C. Jacobson,C. R. Chapman. Effects of Combining Propofol and Alfentanil on Ventilation, Analgesia,Sedation, and Emesis in Human Volunteers[J]. Anesthe siology,1996,84(1).
[12] Jaap Vuyk,Frank H. M. Engbers, Anton G. L. Burm,Arie A. Vletter,Gerard E.R.Griever,Erik Olofsen,James G. Bovill. Pharmacodynamic Interaction between Propofol and Alfentanil When Given for Induction of Anesthesia[J]. Anesthesi ology,1996,84(2).
[13] Donald R.Miller,Raymond J.Mar tineau,Heather OʼBrien,Kathryn A. Hull, Linda Oliveras,Thomas Hindmarsh,Donald Greenway. Effects of Alfentanil on the Hemodynamic and Catecholamine Respo nse to Tracheal Intubation[J]. Anesthe sia & Analgesia,1993,76(5).
[14] Jabbour-Khoury Samar I,Dabb ous Aliya S,Rizk Laudia B,Abou Jalad Naji M,Bartelmaos Tonine E,El-Khatib Mohamad F,Baraka Anis S. A combination of alfentanil-lidocaine-propofol prov ides better intubating conditions than fentanyl-lidocaine-propofol in the absence of muscle relaxants.[J]. Canad ian journal of anaesthesia = Journal canadien d'anesthesie,2003,50(2).
[15] Audrey Shafer,Man-Ling Sung, Paul F. White. Pharmacokinetics and Pha rmacodynamics of Alfentanil Infusions during General Anesthesia[J]. Anesthe sia & Analgesia,1986,65(10):
[16] Gordon Peter C.,Morrell David F.,Pamm Julian D.. Total intravenous an esthesia using propofol and alfentanil for coronary artery bypass surgery[J]. W.B. Saunders,1994,8(3):
[17] Van Aken H,Van Hemelrijck J,Merckx L,Möllhoff T,Mulier J,Lübbesm eyer H J. [Total intravenous anesthesia using propofol and alfentanil in comparison with balanced anesthesia in neurosurgery].[J]. Anasthesie, Intensiv therapie, Notfallmedizin,1990,25(1):
[18] Van Hemelrijck Jan,Van Aken Hugo,Merckx Luc,Mulier Jan. Anesthesia for craniotomy: Total intravenous anes thesia with propofol and alfentanil compared to anesthesia with thiopental sodium, isoflurane, fentanyl, and nitro us oxide[J]. Elsevier,1991,3(6):
[19] 高宇晨,王越夫,王春蓉,等.成年人心脏手术快速通道麻醉对术后并发症影响的研究进展[J].国际麻醉学与复苏杂志,2019,4(06):585-589.
[20] Ahonen J,Olkkola K T,Hynynen M,Seppälä T,Ikävalko H,Remmerie B,Salm enperä M. Comparison of alfentanil, fentanyl and sufentanil for total intravenous anaesthesia with propofol in patients undergoing coronary artery bypass surgery.[J]. British journal of anaesthesia,2000,85(4):
[21] Hynynen M,Takkunen O,Salmenp erä M,Haataja H,Heinonen J. Continuous infusion of fentanyl or alfentanil for coronary artery surgery. Plasma opiate concentrations, haemodynamics and pos toperative course.[J]. British journal of anaesthesia,1986,58(11):
[22] D.W.Blake,C.F.Royse,A.G.Royse,A. R.Bjorksten,P.F.Soeding,J.Pang.Alfentanil Infusion as a Component of Intra venous Anaesthesia for Coronary Artery Bypass Surgery with “Fast-track”Recovery[J]. Anaesthesia and Intensive Care,2003,31(2):
[23] Janet D.Pavlin,Rosalin H.Arends, Holly C. Gunn,Gail Van Norman,Meagan E. Koerschgen,Danny D. Shen. Optimal Pro pofol-Alfentanil Combinations for Su pplementing Nitrous Oxide for Outpati ent Surgery[J].Anesthesiology,1999,91(1):
[24] 覃慧君,黄守国.足月分娩应激反应的研究进展[J].海南医学,2014,25(3):387-389.
[25] Hill D A,McCarthy G,Bali I M. Epidural infusion of alfentanil or dia morphine with bupivacaine in labour- -a dose finding study.[J]. Anaesthesia, 1995,50(5):
[26] D.A.Hughes,D. A. Hill. Intrathe cal alfentanil with and without bupiva caine for analgesia in labour[J]. Anaes thesia,2000,55(11):
Copyright © 2021 崔洁, 刘红梅
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License