Construction and Analysis of Immune Infiltration-Related ceRNA Network for Coronary Artery Disease
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i1.1803
Abstract
This study investigated the role of ceRNA networks in coronary atherosclerosis, focusing on genes co-expression with immune cells. Data from the GEO database was used for GO/KEGG analysis of DE-mRNA, and ceRNA networks were constructed via Cytoscape using predicted lncRNA-miRNA-mRNA regulatory pairs. The CIBERSORT algorithm assessed immune cell proportions, revealing significant correlations between specific immune cells and hub mRNAs in the ceRNA network, particularly involving ESR1. The findings offer new insights into the molecular mechanisms of atherosclerosis and potential diagnostic and therapeutic targets.
Keywords
atherosclerosis, ceRNA, immune cell infiltration, GEO, co-expression
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[6] P. Jakob, T. Kacprowski, S. Briand-Schumacher, D. Heg, R. Klingenberg, B.E. Stähli, M. Jaguszewski, N. Rodondi, D. Nanchen, L. Räber, P. Vogt, F. Mach, S. Windecker, U. Völker, C.M. Matter, T.F. Lüscher, U. Landmesser, Profiling and validation of circulating microRNAs for cardiovascular events in patients presenting with ST-segment elevation myocardial infarction, European heart journal 38(7) (2017) 511-515.
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[11] D. Cheng, B. Liang, Y. Hao, W. Zhou, Estrogen receptor α gene polymorphisms and risk of Alzheimer's disease: evidence from a meta-analysis, Clinical interventions in aging 9 (2014) 1031-8.
[12] M.S. Ali Sheikh, The mir-21 Inhibition Enhanced HUVEC Cellular Viability during Hypoxia-Reoxygenation Injury by Regulating PDCD4, Mediators of inflammation 2022 (2022) 9661940.
[13] J. Choi, S. Crotty, Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (T(FH)), Trends in immunology 42(4) (2021) 336-349.
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