The Clinical Progress of the Combined Treatment of Lung and Intestine on Immune Response
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i1.1796
Abstract
Lung-intestinal homoeopathy is a comprehensive therapeutic strategy that combines traditional theories of traditional Chinese medicine and modern medical concepts. We review the clinical progress of lung-gut homoeopathy on immune function. aiming to positively affect the immune function of patients with lung diseases. By regulating the intestinal microbiota, influencing intestinal mucosal immunity, and modulating immune mediators, some clinical treatments has been proved to be effective. In addition, lung-intestinal homoeopathy can improve the immune function of patients with lung diseases by regulating the expression of immunity and immune mediators in the intestinal mucosa and influencing the play of immune response. Although lung-intestinal homoeopathy has made some progress in the regulation of immune function, further clinical studies are needed to verify its efficacy and safety.
Keywords
lung-gut axis, immunity, clinical, Chinese medicine
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[3] LI R, LI J, ZHOU X. Lung microbiome: new insights into the pathogenesis of respiratory diseases [J]. Signal Transduction and Targeted Therapy, 2024, 9(1).
[4] Li Xiaojun, Li Ya, Li Suyun. Research Progress on the Correlation between Intestinal and Pulmonary Microbiota and Chronic Obstructive Pulmonary Disease [J]. Chinese General Practice Medicine, 2019, 22(35): 4353-7.
[5] Jiang Jialong, Xu Peng, Lou Liming, et al. Clinical Study of "Lung and Intestine Combined Treatment" in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Treated with Mechanical Ventilation for Lung Heat Syndrome [J]. Journal of Zhejiang Chinese Medical University, 2023, 47(12): 1457-62.
[6] Xu Qian, Tan Xi, Hu Tingting, et al. Analysis of Intestinal and Pulmonary Inflammatory Type 2 Innate Lymphoid Cells (iILC2) and Related Cytokine Content in Chronic Obstructive Pulmonary Disease [J]. Journal of Cellular and Molecular Immunology,2023, 39(07): 599-603.
[7] WANG L, PELGRIM C E, PERALTA MARZAL L N, et al. Changes in intestinal homeostasis and immunity in a cigarette smoke- and LPS-induced murine model for COPD: the lung-gut axis [J]. Am J Physiol Lung Cell Mol Physiol, 2022, 323(3): L266-l80.
[8] JIAO L, LI H, XU J, et al. The Gastrointestinal Tract Is an Alternative Route for SARS-CoV-2 Infection in a Nonhuman Primate Model [J]. Gastroenterology, 2021, 160(5): 1647-61.
[9] Xu Wentao, Wang Xuefeng, Yang Jianshu, et al. Effects of Xuanbai Chengqi Decoction on Pulmonary-Intestinal Immune Damage Induced by Co-infection of Influenza Virus and Streptococcus pneumoniae [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2023, 43(11): 1350-8. [10] WEN L, SHI L, KONG X L, et al. Gut Microbiota Protected Against pseudomonas aeruginosa Pneumonia via Restoring Treg/Th17 Balance and Metabolism [J]. Front Cell Infect Microbiol, 2022, 12: 856633.
[11] NYANGAHU D D, PLUMLEE C R, BROWN B P, et al. Antibiotic Treatment during Gestation Enhances Susceptibility to Mycobacterium tuberculosis in Offspring [J]. Microbiol Spectr, 2022, 10(6): e0249122.
[12] SCHULIGA M, READ J, KNIGHT D A. Ageing mechanisms that contribute to tissue remodeling in lung disease [J]. Ageing Research Reviews, 2021, 70.
[13] Zhang Minghui, Ji Meng, Gao Jingdong, et al. Research Progress on the Mechanism of Anti-fibrotic Effects of Traditional Chinese Medicine Polysaccharides [J]. Chinese Traditional and Herbal Drugs, 2024, 55(04): 1063-74. [14] GURCZYNSKI S J, LIPINSKI J H, STRAUSS J, et al. Horizontal transmission of gut microbiota attenuates mortality in lung fibrosis [J]. JCI Insight, 2023, 9(1).
[15] ZHAO C, BU E, ZHANG C, et al. Deciphering the molecular mechanisms of Maxing Huoqiao Decoction in treating pulmonary fibrosis via transcriptional profiling and circRNA-miRNA-mRNA network analysis [J]. Phytomedicine, 2023, 115: 154754.
[16] Liu Enshun, Su Jingshen, Sun Zengtao, et al. Experimental Study on the Effects of Tonic and Diuretic Method on Immune Inflammatory Injury in ALI/ARDS Rats [J]. Tianjin Journal of Traditional Chinese Medicine, 2011, 28(02): 97-100.
[17] WANG Y, WANG Y, MA J, et al. YuPingFengSan ameliorates LPS-induced acute lung injury and gut barrier dysfunction in mice [J]. J Ethnopharmacol, 2023, 312: 116452.
[18] SAPRA L, SAINI C, DAS S, et al. Lactobacillus rhamnosus (LR) ameliorates pulmonary and extrapulmonary acute respiratory distress syndrome (ARDS) via targeting neutrophils [J]. Clin Immunol, 2024, 258: 109872.
[19] ZHAO X, LIU C, PENG L, et al. Metformin facilitates anti-PD-L1 efficacy through the regulation of intestinal microbiota [J]. Genes Immun, 2024, 25(1): 7-13.
[20] ZHU X, LI K, LIU G, et al. Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell [J]. Gut Microbes, 2023, 15(2): 2249143.
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