The Mechanism of Action and Clinical Research Progress of Gastrodin in the Treatment of Vertigo
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i1.1787
Abstract
Gastrodin is a phenolic glycoside with the chemical name of 4-hydroxybenzyl alcohol-β-D-glucopyranoside, which is the main bioactive component of Gastrodia in China. Gastrodin has low toxicity, good sedative and sleeping effects, can effectively dilate the body's blood vessels, increase myocardial blood flow, have a protective effect on the body's nerve cells, and play a role in regulating the excitation and inhibition of the cerebral cortex in the central nervous system, improving vestibular function, anti-inflammatory, antioxidant and other effects, thereby improving the clinical dizziness and other symptoms of patients. Gastrodin injection has good clinical effect in the treatment of vertigo, and no obvious adverse reactions have been observed. Compared with gastrodin alone in the treatment of vertigo, the combination with promethazine, diphenhydramine, betahistine and other drugs can effectively improve the treatment rate and reduce the incidence of related side effects.
Keywords
gastrodin, vertigo, combination therapy
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[2] Li J P. Clinical effect of gastrodin injection combined with Xuesaitong in the treatment of post-circulation ischemic vertigo [J]. Journal of Baotou Medical College, 2016, (6)32:83-84.
[3] Chen, L., Liu, X., Wang, H., and Qu, M. (2017). Gastrodin attenuates pentylenetetrazole-induced seizures by modulating the mitogen-activated protein kinase-associated inflammatory responses in mice. Neurosci. Bull. 33, 264-272. DOI: 10.1007/s12264-016-0084-z
[4] Guan Jinqi, Sun Pingping, Bian Jing et al. Gastrodin can reduce inflammation in ischemic stroke rats [J]. Journal of Tissue Engineering, 2017,28(28):4535-4540.
[5] Zhong, L. M., Bai, Y., Ai, Q. L., Lu, D., Wu, Y. F., Bian, L. G., et al. (2016). Anti-oxidant effect of gastrodin in epilepsy rats. J. Kunming Med. Univ. 37, 5-8.
[6] Guo Z, Yang X, Wu M, Shen A, Li J, Zhang X, Cheng Y, Xie Q, Peng J. Gastrodin attenuates angiotensin II-induced vascular contraction and MLCK/p-MLC2 pathway activation. Pharm Biol. 2023 Dec; 61(1): 858-867. The doi: 10.1080/13880209.2023.2207591. PMID: 37211627; PMCID: PMC10202000.
[7] Ye Yunfei, Zou Kaifeng, Chen Guanghuan. Clinical efficacy of gastrodin injection combined with promethazine injection in the treatment of emergency vertigo [J]. World Journal of Compound Medicine, 2019, 9(11): 115-118.
[8] Guo Ling, Chen Yuxia. Clinical study of gastrodin injection combined with betahistine mesylate tablets in the treatment of postcirculation ischemic vertigo [J]. Gansu Science and Technology, 2019, 35(12): 86-88.
[9] Zhang Shupei, Xu Yanxia. Of gastrodine injection in the treatment of acute vertigo effect evaluation [J]. Chinese medicine abstract (otolaryngology science), 2023, 42(5): 109-111+129. DOI: 10.19617/j.issn1001-1307.2023.05.109.
[10] Li Xiuhua. Effect of gastrodin injection combined with diphenhydramine on vertigo [J]. Chinese Community Physician, 2022, 38(12): 86-88.
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