Research Progress of Single-cell RNA Sequencing in Esophageal Cancer
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v4i4.1391
Abstract
Esophageal cancer (EC) is a highly invasive malignant tumor with early onset, rapid progression, and high risk of recurrence and metastasis. Despite continuous advances in treatment methods, the five-year survival rate has not significantly improved. Single-cell RNA sequencing (scRNA-seq), a high-throughput sequencing technology that has received much attention in recent years, can identify gene expression information at the single-cell level, addressing the issue of cell heterogeneity in traditional sequencing technologies and greatly promoting the development of personalized diagnosis and precision medicine. This article summarizes its latest research progress in studying the tumor microenvironment, metabolic reprogramming, and neoadjuvant chemotherapy in the EC research, providing new insights and ideas for the study, clinical diagnosis, and precision treatment of EC.
Keywords
single-cell RNA sequencing, esophageal cancer, tumor microenvironment, metabolic reprogramming, neoadjuvant chemotherapy
Full Text
PDF - Viewed/Downloaded: 3 TimesReferences
[1] Abnet C C, Arnold M, Wei W Q. Epidemiology of Esophageal Squamous Cell Carcinoma [J]. Gastroenterology, 2018, 154(2): 360-73.
[2] Coleman H G, Xie S-H, Lagergren J. The epidemiology of esophageal adenocarcinoma [J]. Gastroenterology, 2018, 154(2): 390-405.
[3] Hudson W H, Wieland A. Technology meets TILs: Deciphering T cell function in the -omics era [J]. Cancer Cell, 2023, 41(1): 41-57.
[4] Zhang X, Peng L, Luo Y, et al. Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis [J]. Nat Commun, 2021, 12(1): 5291.
[5] Chen Z, Zhao M, Liang J, et al. Dissecting the single-cell transcriptome network underlying esophagus non-malignant tissues and esophageal squamous cell carcinoma [J]. EBioMedicine, 2021, 69(103459.
[6] Nakamura S, Ohuchida K, Ohtsubo Y, et al. Single-cell transcriptome analysis reveals functional changes in tumour-infiltrating B lymphocytes after chemotherapy in oesophageal squamous cell carcinoma [J]. Clin Transl Med, 2023, 13(1): e1181.
[7] Chen Z, Huang Y, Hu Z, et al. Dissecting the single-cell transcriptome network in patients with esophageal squamous cell carcinoma receiving operative paclitaxel plus platinum chemotherapy [J]. Oncogenesis, 2021, 10(10): 71.
[8] Croft W, Evans R P T, Pearce H, et al. The single cell transcriptional landscape of esophageal adenocarcinoma and its modulation by neoadjuvant chemotherapy [J]. Mol Cancer, 2022, 21(1): 200.
[9] Zhao W J, Liu Y, Guo J, et al. Prognostic Biomarkers Identification in Esophageal Cancer Based on WGCNA and Single-Cell Analysis [J]. Dis Markers, 2022, 2022(6595778.
[10] Boreel D F, Span P N, Heskamp S, et al. Targeting Oxidative Phosphorylation to Increase the Efficacy of Radio- and Immune-Combination Therapy [J]. Clin Cancer Res, 2021, 27(11): 2970-8.
[11] Dinh H Q, Pan F, Wang G, et al. Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment [J]. Nat Commun, 2021, 12(1): 7335.
[12] Liu X Y, Liu Y B, Xu J C, et al. Single-cell transcriptomic analysis deciphers key transitional signatures associated with oncogenic evolution in human intramucosal oesophageal squamous cell carcinoma [J]. Clin Transl Med, 2023, 13(3): e1203.
[2] Coleman H G, Xie S-H, Lagergren J. The epidemiology of esophageal adenocarcinoma [J]. Gastroenterology, 2018, 154(2): 390-405.
[3] Hudson W H, Wieland A. Technology meets TILs: Deciphering T cell function in the -omics era [J]. Cancer Cell, 2023, 41(1): 41-57.
[4] Zhang X, Peng L, Luo Y, et al. Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis [J]. Nat Commun, 2021, 12(1): 5291.
[5] Chen Z, Zhao M, Liang J, et al. Dissecting the single-cell transcriptome network underlying esophagus non-malignant tissues and esophageal squamous cell carcinoma [J]. EBioMedicine, 2021, 69(103459.
[6] Nakamura S, Ohuchida K, Ohtsubo Y, et al. Single-cell transcriptome analysis reveals functional changes in tumour-infiltrating B lymphocytes after chemotherapy in oesophageal squamous cell carcinoma [J]. Clin Transl Med, 2023, 13(1): e1181.
[7] Chen Z, Huang Y, Hu Z, et al. Dissecting the single-cell transcriptome network in patients with esophageal squamous cell carcinoma receiving operative paclitaxel plus platinum chemotherapy [J]. Oncogenesis, 2021, 10(10): 71.
[8] Croft W, Evans R P T, Pearce H, et al. The single cell transcriptional landscape of esophageal adenocarcinoma and its modulation by neoadjuvant chemotherapy [J]. Mol Cancer, 2022, 21(1): 200.
[9] Zhao W J, Liu Y, Guo J, et al. Prognostic Biomarkers Identification in Esophageal Cancer Based on WGCNA and Single-Cell Analysis [J]. Dis Markers, 2022, 2022(6595778.
[10] Boreel D F, Span P N, Heskamp S, et al. Targeting Oxidative Phosphorylation to Increase the Efficacy of Radio- and Immune-Combination Therapy [J]. Clin Cancer Res, 2021, 27(11): 2970-8.
[11] Dinh H Q, Pan F, Wang G, et al. Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment [J]. Nat Commun, 2021, 12(1): 7335.
[12] Liu X Y, Liu Y B, Xu J C, et al. Single-cell transcriptomic analysis deciphers key transitional signatures associated with oncogenic evolution in human intramucosal oesophageal squamous cell carcinoma [J]. Clin Transl Med, 2023, 13(3): e1203.
Copyright © 2023 Jingjing Liu
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License