How Fructose Affects the Hippocampus
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v3i3.951
Abstract
This review explores the effects of fructose on the hippocampus: hippocampal function and structure, hippocampal neurogenesis, and hippocampal cognitive function. First, this result confirms that excess fructose intake affects the microstructure of pathways connecting the hippocampus to other brain areas. Fructose has the potential to affect neurogenesis in the hippocampus, and a diet high in fructose can impair learning and memory, leading to cognitive impairment. However, further research is needed to apply animal experiments to humans in the future. The literature review focused on the effects of fructose, but a balanced intake of other nutrients also needed to be considered.
Keywords
fructose, hippocampus, memory
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[3] Clark, K.A., Alves, J.M., Jones, S., Yunker, A.G., Luo, S., Cabeen, R.P., Angelo, B., Xiang, A.H. and Page, K.A. 2020. Dietary fructose intake and hippocampal structure and connectivity during childhood. Nutrients. 12(4), p909.
[4] Cisternas, P., Salazar, P., Serrano, F.G., Montecinos-Oliva, C., Arredondo, S.B., Varela-Nallar, L., Barja, S., Vio, C.P., Gomez-Pinilla, F. and Inestrosa, N.C. 2015. Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 1852(11), pp.2379-2390.
[5] Knierim, J.J. 2015. The hippocampus. Current Biology. 25(23), pp.R1116-R1121.
[6] Lorente de Nó, R. 1934. Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system. Journal für Psychologie und Neurologie.
[7] Rizkalla, S.W. 2010. Health implications of fructose consumption: A review of recent data. Nutrition & metabolism. 7(1), pp.1-17.
[8] Sangüesa, G., Cascales, M., Griñán, C., Sánchez, R.M., Roglans, N., Pallàs, M., Laguna, J.C. and Alegret, M. 2018. Impairment of novel object recognition memory and brain insulin signalling in fructose-but, not glucose-drinking female rats. Molecular neurobiology. 55(8), pp.6984-6999.
[9] Scoville, W.B. and Milner, B. 1957. Loss of recent memory after bilateral hippocampal lesions. Journal of neurology, neurosurgery, and psychiatry. 20(1), p11.
[10] Sun, S.Z. and Empie, M.W. 2012. Fructose metabolism in humans–what isotopic tracer studies tell us. Nutrition & metabolism. 9(1), pp.1-15.
[11] Van der Borght, K., Köhnke, R., Göransson, N., Deierborg, T., Brundin, P., Erlanson-Albertsson, C. and Lindqvist, A. 2011. Reduced neurogenesis in the rat hippocampus following high fructose consumption. Regulatory peptides. 167(1), pp.26-30.
[12] Wu, H.-W., Ren, L.-F., Zhou, X. and Han, D.-W. 2015. A high-fructose diet induces hippocampal insulin resistance and exacerbates memory deficits in male Sprague-Dawley rats. Nutritional Neuroscience. 18(7), pp.323-328.
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