Chronic Neurobrucellosis Investigated via Metagenomic Next-generation Sequencing
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v1i1.110
Abstract
We found that NGS technology has great significance for the diagnosis of brucellosis in non-epidemic area and can rule out other infections. The number of Brucella gene fragments detected by NGS may be affected by clinical resistance to Brucella treatment and Brucella infection. The sensitivity of SAT to detect Brucella may is limited.
Keywords
central nervous system infection, cerebrospinal fluid, cetagenomic second-generation sequencing technology, diagnosis
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[3] Mohseni K, Mirnejad R, Piranfar V, Mirkalantari S. A Comparative Evaluation of ELISA, PCR, and Serum Agglutination Tests For Diagnosis of Brucella Using Human Serum. Iran J Pathol. 2017; 12: 71-76.
[4] Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K. A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China. Biomed Res Int. 2018.
[5] Wilson MR, Naccache SN, Samayoa E, Biagtan M, Bashir H, Yu G, et al. Actionable diagnosis of neuroleptospirosis by next-generation sequencing. N Engl J Med. 2014; 370: 2408-17.
[6] Mongkolrattanothai K, Naccache SN, Bender JM, Samayoa E, Pham E, Yu G, et al. Neurobrucellosis: Unexpected Answer From Metagenomic Next-Generation Sequencing. J Pediatric Infect Dis Soc. 2017; 6: 393-398.
[7] Fan S, Ren H, Wei Y, Mao C, Ma Z, Zhang L, et al. Next-generation sequencing of the cerebrospinal fluid in the diagnosis of neurobrucellosis. Int J Infect Dis. 2018; 67: 20-24.
[8] Dasari S, Naha K, Prabhu M. Brucellosis and tuberculosis: clinical overlap and pitfalls. Asian Pac J Trop Med. 2013; 6: 823-825.
[9] Ulu-Kilic A, Metan G, Alp E. Clinical presentations and diagnosis of brucellosis. Recent Pat Antiinfect Drug Discov. 2013; 8 : 34-41.
[10] Tang Y, Lin L, Sebastian A, Lu H. Detection and characterization of two co-infection variant strains of avian orthoreovirus (ARV) in young layer chickens using next-generation sequencing (NGS). Sci Rep. 2016; 6: 24519.
Copyright © 2020 Yun Zhang, Xiaodan Shi, Xiaofei Fei, Guodong Feng, Gang Zhao*
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