急性一氧化碳中毒迟发性脑病免疫学机制研究进展
Journal: Basic Medical Theory Research DOI: 10.32629/bmtr.v2i3.1674
Abstract
一氧化碳中毒是急诊科常见的中毒性疾病,可同时并发多种严重疾病,极大地影响着人们的健康。其中,一氧化碳中毒后迟发性脑病是一氧化碳中毒最常见的并发症,严重影响患者后期的生活质量。关于一氧化碳中毒机制的学说有很多,但目前尚无统一定论。一氧化碳中毒后迟发性脑病的发病机制大致可以归纳为以下几种学说：免疫反应学说、缺血缺氧学说、细胞凋亡与细胞自噬学说、缺血-再灌注及自由基损伤学说、兴奋性氨基酸学说等。我们对该病发病机制进行综述,以便为今后预测一氧化碳中毒后迟发性脑病提供新的方法和新思路。
Keywords
急性一氧化碳中毒；一氧化碳中毒迟发性脑病；免疫学机制
Full Text
PDF - Viewed/Downloaded: 20 TimesIndexation
Download Index RecordReferences
[1] Raub JA,Mathieu-Nolf M,HampsonNB,et al.Carbon monoxide poisoning--a public health perspective[J].Toxicology,2000,145(1):1-14.
[2] Xiang W, Xue H, Wang B, et al.Combined application of dexamethasoneand hyperbaric oxygen therapy yieldsbetter efficacy for patients withdelayed encephalopathy after acutecarbon monoxide poisoning[J].Drug design,development and therapy,2017,11:513-519.
[3] Azurmendi L, Degos V, Tiberti N,et al. Neopterin plasma concentrationsin patients with aneurysmal subarachnoidhemorrhage: correlation with infectionand long-term outcome[J]. J Neurosurg,2016,124(5):1287-1299.
[4] 周永林,冀亚兵.高压氧联合依达拉奉治疗一氧化碳中毒迟发性脑病临床研究[J].基层医学论坛,2012,(31):4101-4102.
[5] Onec B, Okutan H, Albayrak M, etal.The Predictive Role of the Neutrophil/Lymphocyte Ratio in Survival with MultipleMyeloma: A Single Center Experience[J].J Clin Lab Anal,2017,31(2):1-8.
[6] Gibson PH, Croal BL, CuthbertsonBH, et al. Preoperative neutrophil-lymphocyte ratio and outcome fromcoronary artery bypass grafting[J]. AmHeart J,2007,154(5):995-1002.
[7] Feng JF, Huang Y, Chen QX.Preoperative platelet lymphocyte ratio(PLR)is superior to neutrophil lymphocyteratio (NLR) as a predictive factor inpatients with esophageal squamous cellcarcinoma[J].World J Surg Oncol,2014,12:58.
[8] 张娴,刘若伟,蒲立志,等.血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值与早期一氧化碳中毒程度的关系[J].广西医科大学学报,2018,35(8):1089-1092.
[9] 余小骊,刘莉琼,吴豫,等.一氧化碳中毒及迟发性脑病与血清中免疫相关细胞因子的表达[J].中国免疫学杂志,2014,30(1):121-122+125.
[10] 张前燕,朱滨,冯家银,等.一氧化碳中毒后迟发性脑病患者S100β、JNK通路蛋白及相关细胞因子水平变化及其临床意义[J].中国神经免疫学和神经病学杂志,2018,25(3):198-201.
[11] 张振贵,景建军,俞作发,等.C-反应蛋白预测急性一氧化碳中毒并迟发性脑病的价值[J].新疆医学,2019,49(3):244-247.
[12] 魏钢,孙学斌,桑玉婷,等.急性一氧化碳中毒患者超敏C-反应蛋白变化与预后关系研究[J].宁夏医学杂志,2017,39(2):170-172.
[13] 曹小彪,陈同欣,李金声,等.急性一氧化碳中毒大鼠脑内MIP-1α和ICAM-1的表达及高压氧干预后的变化[J].中国急救医学,2011,31(11):999-1002.
[14] 韩永燕,王岩,赵国强,等.中性粒细胞与淋巴细胞比值和急性一氧化碳中毒心肌损伤的关系[J].中华劳动卫生职业病杂志,2018,36(5):362-364.
[15] Fan DF, Hu HJ, Sun Q, et al.Neuroprotective effects of exogenousmethane in a rat model of acute carbonmonoxide poisoning[J].Brain Res,2016,1633:62-72.
[16] Jang DH, Kelly M, Hardy K, etal. A preliminary study in thealterations of mitochondrial respirationin patients with carbon monoxidepoisoning measured in blood cells[J].Clinical toxicology (Philadelphia, Pa),2017,55(6):579-584.
[17] Pilgrim JL, Jenkins EL, Baber Y,et al. Fatal acute poisonings inAustralianchildren(2003-13)[J].Addiction(Abingdon,England),2017,112(4):627-639.
[18] 黄博雅.高压氧对一氧化碳中毒迟发性脑病小鼠的影响及机制的研究[D].内蒙古医科大学,2017.
[19] 曹义战,李金声,晋兴,等.急性一氧化碳中毒大鼠迟发性神经元损伤与记忆功能改变[J].中国急救医学,2002,22(10):569-571.
[20] 李晟,陈潜妙,池学锋,等.急性一氧化碳中毒后迟发性脑病预测因子的研究[J].浙江医学,2019,41(11):1150-1153.
[21] Goda N, Ryan HE, Khadivi B, etal. Hypoxia-inducible factor 1alpha isessential for cell cycle arrest duringhypoxia[J].Mol Cell Biol,2003,23(1):359-369.
[22] Hynd MR, Scott HL, Dodd PR.Glutamate-mediated excitotoxicity andneurodegeneration in Alzheimer's disease[J].NeurochemInt,2004,45(5):583-595.
[2] Xiang W, Xue H, Wang B, et al.Combined application of dexamethasoneand hyperbaric oxygen therapy yieldsbetter efficacy for patients withdelayed encephalopathy after acutecarbon monoxide poisoning[J].Drug design,development and therapy,2017,11:513-519.
[3] Azurmendi L, Degos V, Tiberti N,et al. Neopterin plasma concentrationsin patients with aneurysmal subarachnoidhemorrhage: correlation with infectionand long-term outcome[J]. J Neurosurg,2016,124(5):1287-1299.
[4] 周永林,冀亚兵.高压氧联合依达拉奉治疗一氧化碳中毒迟发性脑病临床研究[J].基层医学论坛,2012,(31):4101-4102.
[5] Onec B, Okutan H, Albayrak M, etal.The Predictive Role of the Neutrophil/Lymphocyte Ratio in Survival with MultipleMyeloma: A Single Center Experience[J].J Clin Lab Anal,2017,31(2):1-8.
[6] Gibson PH, Croal BL, CuthbertsonBH, et al. Preoperative neutrophil-lymphocyte ratio and outcome fromcoronary artery bypass grafting[J]. AmHeart J,2007,154(5):995-1002.
[7] Feng JF, Huang Y, Chen QX.Preoperative platelet lymphocyte ratio(PLR)is superior to neutrophil lymphocyteratio (NLR) as a predictive factor inpatients with esophageal squamous cellcarcinoma[J].World J Surg Oncol,2014,12:58.
[8] 张娴,刘若伟,蒲立志,等.血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值与早期一氧化碳中毒程度的关系[J].广西医科大学学报,2018,35(8):1089-1092.
[9] 余小骊,刘莉琼,吴豫,等.一氧化碳中毒及迟发性脑病与血清中免疫相关细胞因子的表达[J].中国免疫学杂志,2014,30(1):121-122+125.
[10] 张前燕,朱滨,冯家银,等.一氧化碳中毒后迟发性脑病患者S100β、JNK通路蛋白及相关细胞因子水平变化及其临床意义[J].中国神经免疫学和神经病学杂志,2018,25(3):198-201.
[11] 张振贵,景建军,俞作发,等.C-反应蛋白预测急性一氧化碳中毒并迟发性脑病的价值[J].新疆医学,2019,49(3):244-247.
[12] 魏钢,孙学斌,桑玉婷,等.急性一氧化碳中毒患者超敏C-反应蛋白变化与预后关系研究[J].宁夏医学杂志,2017,39(2):170-172.
[13] 曹小彪,陈同欣,李金声,等.急性一氧化碳中毒大鼠脑内MIP-1α和ICAM-1的表达及高压氧干预后的变化[J].中国急救医学,2011,31(11):999-1002.
[14] 韩永燕,王岩,赵国强,等.中性粒细胞与淋巴细胞比值和急性一氧化碳中毒心肌损伤的关系[J].中华劳动卫生职业病杂志,2018,36(5):362-364.
[15] Fan DF, Hu HJ, Sun Q, et al.Neuroprotective effects of exogenousmethane in a rat model of acute carbonmonoxide poisoning[J].Brain Res,2016,1633:62-72.
[16] Jang DH, Kelly M, Hardy K, etal. A preliminary study in thealterations of mitochondrial respirationin patients with carbon monoxidepoisoning measured in blood cells[J].Clinical toxicology (Philadelphia, Pa),2017,55(6):579-584.
[17] Pilgrim JL, Jenkins EL, Baber Y,et al. Fatal acute poisonings inAustralianchildren(2003-13)[J].Addiction(Abingdon,England),2017,112(4):627-639.
[18] 黄博雅.高压氧对一氧化碳中毒迟发性脑病小鼠的影响及机制的研究[D].内蒙古医科大学,2017.
[19] 曹义战,李金声,晋兴,等.急性一氧化碳中毒大鼠迟发性神经元损伤与记忆功能改变[J].中国急救医学,2002,22(10):569-571.
[20] 李晟,陈潜妙,池学锋,等.急性一氧化碳中毒后迟发性脑病预测因子的研究[J].浙江医学,2019,41(11):1150-1153.
[21] Goda N, Ryan HE, Khadivi B, etal. Hypoxia-inducible factor 1alpha isessential for cell cycle arrest duringhypoxia[J].Mol Cell Biol,2003,23(1):359-369.
[22] Hynd MR, Scott HL, Dodd PR.Glutamate-mediated excitotoxicity andneurodegeneration in Alzheimer's disease[J].NeurochemInt,2004,45(5):583-595.
Copyright © 2020 高红雨, 张援月, 邱绘颖, 陈进玲, 成颖
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License