芬太尼及阿芬太尼在儿童体内的药代动力学的研究进展
Journal: Basic Medical Theory Research DOI: 10.32629/bmtr.v2i2.778
Abstract
芬太尼及其衍生物-阿芬太尼输注后不仅起效快而且其心血管反应也相对稳定,而且具有良好的镇痛和镇静作用,如今已经广泛应用于小儿麻醉。由于小儿不同年龄阶段的神经系统和肝肾等各个器官发育尚未完善并且差异很大,所以阿片类药物应用于小儿体内发生并发症甚至致命性损伤的风险极高。此外,在小儿阿片类药物相关研究数据中仅有有限的药代动力学数据可供麻醉医生实施小儿麻醉时参考。
Keywords
芬太尼；阿芬太尼；小儿；药代动力学
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[2] Olive G.Pharmacocinétique et biotransformation des m
[3] Stanley TH. The history and development of the fentanyl series. J Pain Symptom Manag. 1992;7(3 Suppl.):S3-7.
[4] Rosaeg OP, Kitts JB, Koren G, Byford LJ. Maternal and fetal effects of intravenous patient-controlled fentanyl analgesia during labour in a thrombocytopenic parturient. Can J Anaesth. 1992;39(3):277-81.
[5] Singleton MA, Rosen JI, Fisher DM. Plasma concentrations of fentanyl in infants, children and adults. Can J Anaesth. 1987;34(2):152-5.
[6] Katz R, Kelly HW. Pharmacokinetics of continuous infusions of f e n t a n y l i n c r i t i c a l l y i l l c h i l d r e n . C r i t C a r e M e d . 1 9 9 3 ; 2 1 ( 7 ) :995–1000.
[7] Ginsberg B, Howell S, Glass PS, Margolis JO, Ross AK, Dear GL, et al. Pharmacokinetic model-driven infusion of fentanyl in children. Anesthesiology. 1996;85(6):1268-75.
[8] Vaughns JD, Ziesenitz VC, Williams EF, Mushtaq A, Bachmann R, Skopp G, et al. Use of fentanyl in adolescents with clinically severe obesity undergoing bariatric surgery: a pilot study. Pediatr Drugs 2017;19(3):251-7.
[9] Katz R, Kelly HW. Pharmacokinetics of continuous infusions of fentanyl in critically ill children. Crit Care Med. 1993;21(7):995-1000.
[10] Arnold JH, Truog RD, Orav EJ, Scavone JM, Hershenson MB. Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology. 1990;73(6):1136-40.
[11] Collins C, Koren G, Crean P, Klein J, Roy WL, MacLeod SM. Fentanyl pharmacokinetics and hemodynamic effects in preterm infants during ligation of patent ductus arteriosus. Anesth Analg. 1985;64(11):1078-80.
[12] Wilson AS, Stiller RL, Davis PJ, Fedel G, Chakravorti S, Israel BA, et al. Fentanyl and alfentanil plasma protein binding in preterm and term neonates. Anesth Analg. 1997;84(2):315-8.
[13] Meistelman C, Saint-Maurice C, Lepaul M, Levron JC, Loose JP, Mac Gee K. A comparison of alfentanil pharmacokinetics in children and adults. Anesthesiology. 1987;66(1):13-6.
[14] Davis PJ, Stiller RL, Cook DR, Brandom BW, Davis JE, Scierka AM. Effects of cholestatic hepatic disease and chronic renal failure on alfentanil pharmacokinetics in children. Anesth Analg. 1989;68(5):579-83.
[15] Murphy MR, Hug CC Jr, McClain DA. Dose-independent pharmacokinetics of fentanyl. Anesthesiology. 1983;59(6):537-40.
[16] den Hollander JM, Hennis PJ, Burm AG, Bovill JG. Alfentanil in infants and children with congenital heart defects. J Cardiothorac Anesth. 1988;2(1):12–7.
[17] Killian A, Davis PJ, Stiller RL, Cicco R, Cook DR, Guthrie RD. Influence of gestational age on pharmacokinetics of alfentanil in neonates. Dev Pharmacol Ther. 1990;15(2):82–5.
[18] Pokela ML, Ryhanen PT, Koivisto ME, Olkkola KT, Saukkonen AL. Alfentanil-induced rigidity in newborn infants. Anesth Analg. 1992;75(2):252–7.
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