多氯联苯与糖尿病关联的研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i2.6959
Abstract
多氯联苯是一种持久性有机污染物,广泛存在于环境中。糖尿病近年来广泛流行,成为危害人体健康的慢性病之一。大量的动物实验和机制研究表明多氯联苯和糖尿病存在关联性,研究结果为预防糖尿病提供更多循证医学参考。
Keywords
多氯联苯；糖尿病；综述
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[13] Christensen, K. Y., Raymond, M. R., Thompson, B. A., & Anderson, H. A. (2016). Fish Consumption, Levels of Nutrients and Contaminants, and Endocrine-Related Health Outcomes Among Older Male Anglers in Wisconsin. Journal of occupati onal and environmental medicine, 58(7), 668–675. https://doi. org/10.1097/JOM.0000000000000758.
[14] Baker, N. A., Shoemaker, R., English, V., Larian, N., Sunkara, M., Morris, A. J., Walker, M., Yiannikouris, F., & Cassis, L. A. (2015). Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCBInduced Disruption of Glucose Homeostasis in Lean and Obese Mice. Environmental health perspectives, 123(10),944–950.https://doi.org/10.1289/ehp.1408594.
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[18] Bresson,S. E., Isom, S., Jensen, E. T., Huber, S., Oulhote,Y., Rigdon, J., Lovato, J., Liese, A. D., Pihoker, C., Dabelea, D., Ehrlich,S., & Ruzzin, J. (2022). Associations between persistent organic pollutants and type 1 diabetes in youth. Environmentinternational,163,107175.https://doi.org/10.1016/j.envint.2022.107175.
[19] Gourronc,F.A.,Perdew,G.H.,Robertson,L.W.,&Klingelhutz, A. J. (2020). PCB126 blocks the thermogenic beiging response of adipocytes. Environmental science and pollution research international,27(9),8897–8904.https://doi.org/10.1007/s11356-019-06663-0.
[20] Gadupudi, G.,Gourronc, F. A., Ludewig, G., Robertson, L. W., & Klingelhutz, A.J. (2015). PCB126 inhibits adipogenesis ofhuman preadipocytes.Toxicology in vitro: an international jo urnal published in association with BIBRA,29(1), 132-141. https://doi.org/10.1016/j.tiv.2014.09.015.
[21] Jensen,T.K.,Timmermann,A.G.,Rossing,L.I., Ried-Larsen, M., Grøntved, A., Andersen, L. B., Dalgaard, C., Hansen, O. H., Scheike, T., Nielsen, F., & Grandjean, P. (2014). Polychlorinated biphenyl exposure and glucose metabolism in 9-year-old Danish children. The Journal of clinical endocrinology and metabolism,99(12),E2643–E2651.https://doi.org/10.1210/jc.2014-1683.
[22] Mullerova,D.,Pesta,M., Dvorakova, J., Cedikova, M., Kulda, V., Dvorak, P., Bouchalová, V., Kralickova, M., Babuska, V., Kuncova, J.,Langmajerova,J.,& Muller,L.(2017). Polychlorinated biphenyl 153 in lipid medium modulates differentiation of human adipocytes.Physiological research,66(4),653–662.https://doi. org/10.33549/physiolres.933280.
[23] Turyk,M.,Fantuzzi, G., Persky, V., Freels, S., Lambertino, A., Pini, M., Rhodes, D. H., & Anderson, H. A. (2015). Persistent organic pollutants and biomarkers of diabetes risk in a cohort of Great Lakes sport caught fish consumers. Environmental research,140,335344.https://doi.org/10.1016/j.envres.2015.03.037.
[24] Lim,J.E.,& Jee, S. H. (2015). Association between serum levels of adiponectin and polychlorinated biphenyls in Korean men and women. Endocrine,48(1),211–217.https://doi.org/10.1007/s12020-014-0231-0.
[2] Airaksinen, R., Rantakokko, P., Eriksson, J. G., Blomstedt, P., Kajantie, E., & Kiviranta, H. (2011). Association between type 2 diabetes and exposure to persistent organic pollutants. Diabetes care, 34(9), 1972-1979. https://doi.org/10.2337/dc 10-2303.
[3] Kuiper, J., Moran, M., & Cetkovic-Cvrlje, M. (2016). Exp osure to polychlorinated biphenyl-153 decreases incidence of autoimmune Type 1 diabetes in non-obese diabetic mice. Journal of immunotoxicology, 13(6), 850–860. https://doi.org /10.1080/1547691X.2016.1213333.
[4] Loiola, R.A., Dos Anjos, F. M., Shimada, A. L., Cruz, W. S.,Drewes,C.C., Rodrigues, S.F., Cardozo, K. H., Carvalho, V. M., Pinto, E., & Farsky, S. H. (2016). Long-term in vivo polychlorinated biphenyl 126 exposure induces oxidative stress and alters proteomic profile on islets of Langerhans. Scientific reports, 6, 27882. https://doi.org/10.1038/srep27882.
[5] Timme-Laragy,A.R.,Sant, K. E., Rousseau, M. E., & diIorio, P. J. (2015).Deviant development of pancreatic beta cells from embryonic exposure to PCB126 in zebrafish. Comparative bioc hemistry and physiology. Toxicology & pharmacology:CBP,178,25-32.https://doi.org/10.1016/j.cbpc.2015.08.012.
[6] Zhang,S., Wu, T., Chen, M., Guo, Z., Yang, Z., Zuo, Z., & Wang, C. (2015). Chronic Exposure to Aroclor 1254 Disrupts Glucose Homeostasis in Male Mice via Inhibition of the Insulin Rec eptor Signal Pathway. Environmental science & technology,49 (16),1008410092.https://doi.org/10.1021/acs.est.5b01597.
[7] Mesnier,A.,Champion,S.,Louis,L.,Sauzet,C.,May,P.,Portugal, H., Benbrahim, K., Abraldes, J., Alessi, M. C., Amiot-Carlin, M. J., Peiretti, F., Piccerelle, P., Nalbone, G., & Villard, P. H. (2015). The Transcriptional Effects of PCB118 and PCB153 on the Liver, Adipose Tissue, Muscle and Colon of Mice: Highlighting of Glut4 and Lipin1 as Main Target Genes for PCB Induced Metabolic Disorders.PloS one,10(6),e0128847.https://doi.org/ 10.1371/journal.pone.0128847.
[8] Xi,Z.,Fang,L.,Xu, J.,Li, B., Zuo, Z.,Lv, L., & Wang, C. (2019). Exposure to Aroclor 1254 persistently suppresses the func tions of pancreatic β-cells and deteriorates glucose homeos tasis in male mice. Environmental pollution (Barking, Essex : 1987), 249, 822–830. https://doi.org/10.1016/j.envpol.2019. 03.101.
[9] Shi, H., Jan, J., Hardesty, J. E., Falkner, K. C., Prough, R.A., Balamurugan, A. N., Mokshagundam, S. P., Chari, S. T., & Cave, M.C.(2019). Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Impli cations for nonalcoholic steatohepatitis and diabetes. Toxico logy and applied pharmacology,363,22–33.https://doi.org/10. 1016/j.taap.2018.10.011.
[10] Chen,J.,Zhong,L.,Wu, J.,Ke, S.,Morpurgo, B., Golovko, A., Ouyang, N.,Sun, Y., Guo, S., & Tian, Y. (2018). A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals. Journal of visualized experiments:JoVE,(136),57327. https://doi.org/10.3791/57327.
[11] Su, S., Wu, G., Cheng, X., Fan, J., Peng, J., Su, H., Xu, Z., Cao,M.,Long,Z.,Hao,Y.,Li,G.,Li,S.,Hai,C.,& Wang,X. (2018). Oleanolic acid attenuates PCBs-induced adiposity and insulin resista nce via HNF1b-mediated regulation of redox and PPARγsignaling.Free radical biology & medicine,124,122-134. https://doi.org/10.1016/j.freeradbiomed.2018.06.003.
[12] Baker, N. A., Karounos, M., English, V., Fang, J., Wei, Y.,Stromberg, A., Sunkara, M., Morris, A. J., Swanson, H. I., & Cassis, L.A.(2013). Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice. Environmental health perspectives,121(1),105–110.https://doi. org/10.1289/ehp.1205421.
[13] Christensen, K. Y., Raymond, M. R., Thompson, B. A., & Anderson, H. A. (2016). Fish Consumption, Levels of Nutrients and Contaminants, and Endocrine-Related Health Outcomes Among Older Male Anglers in Wisconsin. Journal of occupati onal and environmental medicine, 58(7), 668–675. https://doi. org/10.1097/JOM.0000000000000758.
[14] Baker, N. A., Shoemaker, R., English, V., Larian, N., Sunkara, M., Morris, A. J., Walker, M., Yiannikouris, F., & Cassis, L. A. (2015). Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCBInduced Disruption of Glucose Homeostasis in Lean and Obese Mice. Environmental health perspectives, 123(10),944–950.https://doi.org/10.1289/ehp.1408594.
[15] Gourronc, F. A., Robertson, L. W., & Klingelhutz, A. J. (2018).A delayed proinflammatory response of human pread ipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environmental science and pollution research inte rnational,25(17),16481–16492. https://doi.org/10.1007/s113 56-017-9676-z.
[16] Chen,S.,Xin, J., Ding, Z., Zhao, L., Ben, S., Zheng, R., Li, S., Li, H., Shao, W., Cheng, Y., Zhang, Z., Du, M., & Wang, M. (2023).Construction,evaluation,and AOP framework-based application of the EpPRS as a genetic surrogate for assessing environme ntal pollutants. Environment international, 180, 108202. Adva nce online publication. https://doi.org/10.1016/j.envint.2023. 108202.
[17] Tan,Q., Wang, M.,Yu, L., Liang, R., Liu, W., Dong, C., Zhang, Y., Li, M., Ye, Z., Wang, B., Zhou, M., & Chen, W. (2022). Associations of polychlorinated biphenyls exposure with plasma glucose and diabetes in general Chinese population: The mediating effect of lipid peroxidation. Environmental pollution (Barking,Essex:1987),308,119660.https://doi.org/10.1016/j.envpol.2022.119660.
[18] Bresson,S. E., Isom, S., Jensen, E. T., Huber, S., Oulhote,Y., Rigdon, J., Lovato, J., Liese, A. D., Pihoker, C., Dabelea, D., Ehrlich,S., & Ruzzin, J. (2022). Associations between persistent organic pollutants and type 1 diabetes in youth. Environmentinternational,163,107175.https://doi.org/10.1016/j.envint.2022.107175.
[19] Gourronc,F.A.,Perdew,G.H.,Robertson,L.W.,&Klingelhutz, A. J. (2020). PCB126 blocks the thermogenic beiging response of adipocytes. Environmental science and pollution research international,27(9),8897–8904.https://doi.org/10.1007/s11356-019-06663-0.
[20] Gadupudi, G.,Gourronc, F. A., Ludewig, G., Robertson, L. W., & Klingelhutz, A.J. (2015). PCB126 inhibits adipogenesis ofhuman preadipocytes.Toxicology in vitro: an international jo urnal published in association with BIBRA,29(1), 132-141. https://doi.org/10.1016/j.tiv.2014.09.015.
[21] Jensen,T.K.,Timmermann,A.G.,Rossing,L.I., Ried-Larsen, M., Grøntved, A., Andersen, L. B., Dalgaard, C., Hansen, O. H., Scheike, T., Nielsen, F., & Grandjean, P. (2014). Polychlorinated biphenyl exposure and glucose metabolism in 9-year-old Danish children. The Journal of clinical endocrinology and metabolism,99(12),E2643–E2651.https://doi.org/10.1210/jc.2014-1683.
[22] Mullerova,D.,Pesta,M., Dvorakova, J., Cedikova, M., Kulda, V., Dvorak, P., Bouchalová, V., Kralickova, M., Babuska, V., Kuncova, J.,Langmajerova,J.,& Muller,L.(2017). Polychlorinated biphenyl 153 in lipid medium modulates differentiation of human adipocytes.Physiological research,66(4),653–662.https://doi. org/10.33549/physiolres.933280.
[23] Turyk,M.,Fantuzzi, G., Persky, V., Freels, S., Lambertino, A., Pini, M., Rhodes, D. H., & Anderson, H. A. (2015). Persistent organic pollutants and biomarkers of diabetes risk in a cohort of Great Lakes sport caught fish consumers. Environmental research,140,335344.https://doi.org/10.1016/j.envres.2015.03.037.
[24] Lim,J.E.,& Jee, S. H. (2015). Association between serum levels of adiponectin and polychlorinated biphenyls in Korean men and women. Endocrine,48(1),211–217.https://doi.org/10.1007/s12020-014-0231-0.
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