脓毒症脑病发病机制的研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v6i2.6955
Abstract
脓毒症相关性脑病(SAE)是脓毒症常见的并发症,继发于脓毒症导致的大脑功能异常,以谵妄、昏迷等意识状态改变为主要症状,发病机制复杂,无统一确切的诊断标准,无针对性治疗方案,如今多以对症治疗为主。针对SAE病理生理机制的进一步研究,寻找更有效的干预措施和治疗方案,仍是当下SAE相关领域的重中之重。本文就目前已知的发病机制进行综述。
Keywords
脓毒症相关性脑病；血脑屏障；神经炎症；研究进展
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[3] Chen J, Shi X, Diao M, et al..A retrospective study of sepsis-associated encephalopathy:epidemiology,clinical feat ures and adverse outcomes.BMC Emerg Med2020;20:77.
[4] Annane D, Sharshar T. Cognitive decline after sepsis. Lancet Respir Med.2015 Jan;3(1):61-69.
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[8] Michels M,Vieira AS, et,al.The role of microglia acti vation in the development of sepsis-induced long-term cogn itive impairment. Brain Behav Immun. 2015 Jan;43:54-59.
[9] Nishioku T, Dohgu S, et al.Detachment of brain peric ytes from the basal lamina is involved in disruption of the blood-brain barrier caused by lipopolysaccharide-induced sepsis in mice. Cell Mol Neurobiol. 2009 May;29(3):309-316.
[10] Tang Y, Soroush F, Sun S, et al. Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage.J Neuroinflammation.2018;15(1):309.
[11] Goldim MP, Danielski LG,et,al.Oxidative stress in the choroid plexus contributes to blood-cerebrospinal fluid bar rier disruption during sepsis development. Microvasc Res. 2019 May;123:19-24.
[12] Pan S, Lv Z, Wang R, et al. Sepsis-Induced Brain Dys function: Pathogenesis, Diagnosis, and Treatment.Oxid Med Cell Longev.2022;2022:1328729.
[13] Everson-Rose SA,Ryan JP.Diabetes,Obesity,and the Brain:New Developments in Biobehavioral Medicine.Psychosom Med.2015 Jul-Aug;77(6):612-615.
[14] Yin F, Sancheti H, Patil I, Cadenas E. Energy metab olism and inflammation in brain aging and Alzheimer's disease. Free Radic Biol Med. 2016 Nov;100:108-122.
[15] Stubbs DJ., Yamamoto AK., Menon DK. Imaging in sepsis -associated encephalopathy–insights and opportunities. Nat Rev Neurol.2013;9(10):551-561.
[16] Semmler A, Okulla T, Sastre M, Dumitrescu-Ozimek L, Heneka MT. Systemic inflammation induces apoptosis with vari able vulnerability of different brain regions. J Chem Neuro anat.2005;3:144-157.
[17] Sharshar T, Gray F, et al. Apoptosis of neurons in car diovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet.2003 Nov 29;362(9398):1799-805.
[18] Dahl RH, Berg RMG,et al.A reassessment of the blood -brain barrier transport of large neutral amino acids during acute systemic inflammation in humans. Clin Physiol Funct Imaging.2018 Jul;38(4):656-662.
[19] Zampieri FG, Park M, Machado FS, Azevedo LC. Sepsisassociated encephalopathy:not just delirium.Clinics.2011;66 (10):1825-1831.
[20] Li S, Lv J,et al. Intestinal microbiota impact sepsis associated encephalopathy via the vagus nerve. Neurosci Lett. 2018 Jan 1;662:98-104.
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