系统性红斑狼疮的发病机制研究进展

Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v5i1.5859

周源

中国医学科学院北京协和医学院整形外科医院

Abstract

红斑狼疮是一种由机体自身免疫介导的慢性、反复迁延的自身免疫病。该病为一病谱性疾病,系统性红斑狼疮和皮肤型红斑狼疮分别位于病谱的两端。系统性红斑狼疮在我国患病率为(30.13~70.41)/10万,患者多为青壮年,并且女性远多于男性,男女发病率之比为1:9。其病因及发病机制至今仍未完全明确,可能与遗传、环境、药物、内分泌及免疫紊乱等有关。

Keywords

系统性红斑狼疮;发病机制;基因表达;免疫紊乱;代谢

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